Tytuł artykułu
Autorzy
Treść / Zawartość
Pełne teksty:
Identyfikatory
Warianty tytułu
Konferencja
8th International Conference on Global Research and Education – Inter-Academia 2009
Języki publikacji
Abstrakty
MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.
Słowa kluczowe
Rocznik
Tom
Strony
191--194
Opis fizyczny
Bibliogr. 2 poz., rys.
Twórcy
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
autor
- Department of Materials Science, Graduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan, tcmyama@ipc.shizuoka.ac.jp
Bibliografia
- [1] Bongrtz G., Magn. Reson. Mater. Phy., vol. 20, 2007, pp. 57-62.
- [2] Takahashi M., Hara Y., Yamashita M., et.al., Tetrahedron Lett., vol. 41, 2000, pp. 8485-8488.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ7-0006-0056