Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars

• Autorzy: Sugiyama M. , Yamashita M. , Yu G. , Fujie M. , Ogawa K. , Ozaki N. , Aoki T. , Mizuno S. , Okada S. , Tachi K. , Aoshima K. , Sankar U. R. , Kumar B. S. , Takehara Y. , Sakahara H.
• Konferencja: 8th International Conference on Global Research and Education – Inter-Academia 2009
• Języki publikacji: EN

Abstrakty

EN

MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.

Słowa kluczowe

EN

MRI contrast agent; Gd(III)-DTPA; tumor imaging

• Wydawca: Łukasiewicz Industrial Research Institute for Automation and Measurements PIAP
• Czasopismo: Journal of Automation Mobile Robotics and Intelligent Systems
• Rocznik: 2009
• Tom: Vol. 3, No. 4
• Strony: 191--194
• Opis fizyczny: Bibliogr. 2 poz., rys.

Twórcy

autor

Sugiyama M.

autor

Yamashita M.

autor

Yu G.

autor

Fujie M.

autor

Ogawa K.

autor

Ozaki N.

autor

Aoki T.

autor

Mizuno S.

autor

Okada S.

autor

Tachi K.

autor

Aoshima K.

autor

Sankar U. R.

autor

Kumar B. S.

autor

Takehara Y.

autor

Sakahara H.

• Department of Materials Science, Graduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan,

Bibliografia

• [1] Bongrtz G., Magn. Reson. Mater. Phy., vol. 20, 2007, pp. 57-62.
• [2] Takahashi M., Hara Y., Yamashita M., et.al., Tetrahedron Lett., vol. 41, 2000, pp. 8485-8488.