R&D of novel medicinal materials for curing cancer: sugar modified Gd-DTPA MRI contrast agents and phospha sugar anti-cancer agents

• Autorzy: Yamashita Y. , Yamashita M. , Fujie M. , Suyama K. A. T. , Ito S. , Reddy V. K. , Yamada M. , Ogawa K. , Ozaki N. , Nakamura S. , Aoki T. , Yu G. , Aoshima K. , Kato T. , Kamikage N. , Kiyofuji K. , Takehara Y. , Sakahara H. , Takayanagi H. , Oshikawa T. , Laurent S. , Burtea C. , Van der Elst L. , Muller R. N.
• Konferencja: 8th International Conference on Global Research and Education – Inter-Academia 2009
• Języki publikacji: EN

Abstrakty

EN

Novel Sugar Dendritic Gd-DTPA Complexes for MRI Contrast Agents were prepared and evaluated by in vitro and in vivo methods. The sugar dendritic MRI contrast agents have a good blood vesse pool character, and draw blood vessels and liver cancer remarkably clearer than the clinically using Gd-DTPA. Phospha sugar derivatives or phosphorus heterocyclic derivatives provided by functional groups such as epoxide, bromide, etc., were prepared and evaluated by MTT in vitro method. These phospha sugar derivatives showed excellent activities against leukemia cells as well as solid cancer cells in fashions of (i) higher activity, (ii) wider spectra, (iii) higher selectivity and specificity distingushing healthy and cancer cells, etc., compared with the molecular targeting chemotheraputic anti-cancer agent, Gleevec.

Słowa kluczowe

EN

MRI contrast agent; sugar-ball-dendrimer; Gd (III)-DTPA complex; phospha sugars; phospholanes; anticancer agent; tumor

• Wydawca: Łukasiewicz Industrial Research Institute for Automation and Measurements PIAP
• Czasopismo: Journal of Automation Mobile Robotics and Intelligent Systems
• Rocznik: 2009
• Tom: Vol. 3, No. 4
• Strony: 80--83
• Opis fizyczny: Bibliogr. 5 poz., rys.

Twórcy

autor

Yamashita Y.

autor

Yamashita M.

autor

Fujie M.

autor

Suyama K. A. T.

autor

Ito S.

autor

Reddy V. K.

autor

Yamada M.

autor

Ogawa K.

autor

Ozaki N.

autor

Nakamura S.

autor

Aoki T.

autor

Yu G.

autor

Aoshima K.

autor

Kato T.

autor

Kamikage N.

autor

Kiyofuji K.

autor

Takehara Y.

autor

Sakahara H.

autor

Takayanagi H.

autor

Oshikawa T.

autor

Laurent S.

autor

Burtea C.

autor

Van der Elst L.

autor

Muller R. N.

• Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan,

Bibliografia

• [1] Takahashi M., Hara Y., Yamashita M., et al., Tetrahedron Lett., vol. 41, 2000, pp. 8485-8488.
• [2] H. Lammers, M. Frederic, R. N. Muller, et al., Inorg. Chem., vol. 36, 1997, pp. 2527-2538.
• [3] Yamashita M., Reddy V.K., Rao L.N., Haritha B., Maeda M., Suzuki K., Totsuka H., Takahashi M., Oshikawa T., Tetrahedron Lett., vol. 44, 2003, p. 2339-2341.
• [4] Totsuka H., Maeda M., Reddy V.K., Takahashi M., Yamashita M., Heterocyclic Commun., vol. 10, 2004, p. 295-300.
• [5] Nakamura S., Yamashita M., Yokota D., Hirano I., Ono T., Fujie M., Shibata K., Niimi T., Suyama T., Maddali K., Asai H., Yamashita J., Iguchi Y., Ohnishi K. , Investigational New Drugs, in press (2009)