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Preliminary design and simulation of a spherical brain PET system (SBPET) with liquid xenon as scintillator

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
Czasopismo
Rocznik
Strony
33--38
Opis fizyczny
Bibliogr. 39 poz., rys.
Twórcy
autor
autor
  • Physics Department, University of Isfahan, Hezar jerib Ave., P. O. Box 81745-319, Isfahan, Iran, Tel.: +98 21 2212 7215, Fax: +98 21 8861 3937, mortazavi@alzahra.ac.ir
Bibliografia
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  • 3. Buvate I, Castiglioni I (2002) Monte Carlo simulation in SPET and PET. J Nucl Med 46:48–61
  • 4. Chepel V, Lopes MI, Kurchenkov A, Ferreira Marques R, Policarpo AJPL (1997) Performance study of liquid xenon detector for PET. Nucl Instrum Methods A 392:427–432
  • 5. Chepel V, Lopes M, Solvov V, Ferreira Marques R, Policarpo AJPL (2001) Development of liquid xenon detector for medical imaging. World Sci (28-11-02) 11;58:1–13
  • 6. Collot J, Jan S (2001) A liquid xenon PET camera for neuro-science. In: Proc of the 9th Int Conf Calorimetry in High Energy Physics. arXiv.org/pdf/physics/0211117
  • 7. Cussonneau JP, Carlier T, Couturier O et al. (2005) Simulation and evaluation of a new PET system based on Liquid Xenon as detection medium. ICDL IEEE Int Conf, pp 357–360
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  • 10. Derenzo SE, Weber MJ, Bourret-Courchesne E, Klintenberg MK (2003) The quest for the ideal inorganic scintillator. Nucl Instrum Methods A 505:111–117
  • 11. Doke T, Kikuchi J, Nishikido F (2006) Time of flight positron emission tomograghy using liquid xenon scintillation. Nucl Instrum Methods A 569:863–871
  • 12. Eijk CWE van (2002) Inorganic scintillators in medical imaging. Phys Med Biol 47:R85–R106
  • 13. Gallin-Martel ML, Martin P, Mayet F et al. (2006) Experimental study of a liquid xenon PET prototype module. Nucl Instrum Methods A 563:225–228
  • 14. Herzog H, Tellmann L, Hocke C et al. (2004) NEMA NU2-2001 guided performance evaluation of four Siemens ECAT PET scanners. IEEE Trans Nucl Sci 51;5:2662–2669
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  • 18. Jan S, Collet J, Tournefier E (2000) A liquid xenon PET camera – simulation and position sensitive PMT test. Nuclear Science Symp Conf Record IEEE, pp 23–26
  • 19. Jan S, Santin G, Strul D et al. (2004) Gate: a simulation toolkit for PET and SPECT. arXiv:physics/0408109
  • 20. Karimian A, Thompson CJ, Sarkar S et al. (2004) A dedicated PET system for breast imaging (CYBPET). Nuclear Science and Medical Imaging Symp Conf Record IEEE 4:2339–2341
  • 21. Karimian A, Thompson S, Sarkar S, Raisali G, Pani R (2005) CYBPET: A cylindrical PET system for breast imaging. Nucl Instrum Methods Phys Res A 545:427–435
  • 22. Lartizien C, Comtat C, Kinahan PE, Ferreira N, Bendriem B, Trebossen R (2002) Optimization of injected dose based on noise equivalent count rates for 2- and 3-dimensional whole-body PET. J Nucl Med 43:1268–1278
  • 23. Mortazavi N, Karimian A, Mostajaboddavati M (2006) Design of new dedicated brain PET system by Monte Carlo method. World J Nucl Med 5:S215, 3653
  • 24. Mortazavi Moghaddam N (2007) Design of a new dedicated brain PET system by GATE, EANM 2007, Kopinhag, Denmark: S-158, 179
  • 25. Moses WW, Virador PRG, Derenzo SE, Huesman RH, Budinger TF (1997) Design of a high resolution, highsensitivity PET camera for human brains and small animals. IEEE Trans Nucl Sci 44:1487–1491
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  • 28. Nutt R (2002) The history of positron emission tomography. Mol Imag Biol 4;1:11–26
  • 29. Saha GB (2004) Basics of PET imaging. Springer, New York
  • 30. Santin G, Strul DE, Lazaro D, Simon L, Morel C (2002) Gate: A Geant4 – based simulation platform for PET and SPECT integrating movement and time management. Nuclear Science Symp Conf Record IEEE 2:1325–1329
  • 31. Schmidtlein CR, Kirov AS, Nehmeh SA, Erdi YE (2006) Validation of gate Monte Carlo simulations of the GE advance/discovery LS PET scanner. Med Phys 33;1:198–208
  • 32. Seguinot J, Braem A, Chesi E et al. (2005) Novel geometrical concept of high performance brain PET scanner: principle, design and performance estimates. Pre-print CERN PH EP/2004 050
  • 33. Sossi V (2003) Positron emission tomography (PET) advances in neurological applications. Nucl Instrum Methods A 510:107–115
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  • 39. Zaidi H, Montandon ML (2006) The new challenges of brain technology. Curr Med Imag Rev 2;15:3–13
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ6-0025-0059
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