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Tytuł artykułu

Cyclotron production of 68Ga via proton-induced reaction on 68Zn target

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
68Ga is an important positron-emitting radionuclide for positron emission tomography. In this work 68Ga was produced via the 68Zn(p,n)68Ga nuclear reaction. 68Zn electrodeposition on a copper substrate was carried out by alkaline cyanide baths. 68Zn target was irradiated with a 15 MeV proton beam and a 150 mi A current. The production yield achieved was 136 mCi/ mi Aźh (5.032 GBq/mi Aźh). 68Ga was separated from zinc and copper by a combination of cation exchange chromatography and liquid-liquid extraction methods.
Słowa kluczowe
Czasopismo
Rocznik
Strony
25--28
Opis fizyczny
Bibliogr. 20 poz., rys.
Twórcy
autor
autor
autor
autor
  • Agricultural, Medical and Industrial Research School, P. O. Box 31485-498, Gohardasht, Karaj, Iran, Tel.: +98 261 4436395, Fax: +98 261 4464055,, msadeghi@nrcam.org
Bibliografia
  • 1. Al-Saleh FS, Mugren KS, Azzam A (2007) Excitation function measurements and integral yields estimation for natZn(p,x) reaction at low energies. Appl Radiat Isot 65:1101–1107
  • 2. Anderson CJ, Welch MJ (1999) Radiometal-labeled agents (Non-Technetium) for diagnostic imaging. Chem Rev 99:2219–2234
  • 3. Breeman WA, De Jong M, De Blois E, Bernard BF, Konijnenberg M (2005) Radiolabelling DOTA-peptides with 68Ga. Eur J Nucl Med Mol Imaging 32:478–485
  • 4. Brits RJN, Strelow FWE (1990) 67Ga/Zn separation with an organic adsorbent. Appl Radiat Isot 41:575–578
  • 5. Dasgupta AK, Mausner LF, Srivastava SC (1991) A new separation procedure for 67Cu from proton irradiated zinc. Appl Radiat Isot 42:371–376
  • 6. Fernandes L, Braghhirolli AMS (1982) Extraction chromatography in isotope production of 67Ga and 201Tl. J Labelled Compd Radiopharm 19:1423
  • 7. Green MA, Welch MJ (1989) Gallium radiopharmaceutical chemistry. Nucl Med Biol 16:435–448
  • 8. Hermanne A, Walravens N, Cicchelli O (1991) Optimization of isotope production by cross-section determination. In: Qaim SM (ed) Proc of Int Conf Nuclear Data for Science and Technology, May 1991, Jülich, Germany, Springer-Verlag, Berlin, p 616
  • 9. Koning AJ, Hilaire S, Duijvestijn MC (2008) TALYS-1.0.In: ND 2007 Int Conf on Nuclear Data for Science and Technology, Nice, France. CEA, EDP Sciences. http://dx.doi.org/10.1051/ndata:07767
  • 10. Lahiri S, Banerjee S, Das NR (1997) Simultaneous production of carrier-free 65Zn and 66,67,68Ga in α-particle activated copper target and their separation with TOA. Appl Radiat Isot 48:15–18
  • 11. Liu S, Edwards DS (2001) Bifunctional chelators for therapeutic lanthanide radiopharmaceuticals. Bioconjug Chem 12:17–34
  • 12. Maeke HR, Hofman M, Haberkorn U (2005) 68Ga-labeled peptides in tumor imaging. Nucl Med 46;S1:172S–178S
  • 13. Schwarzbach R, Zimmermann K, Bläuenstein P, Smith A, Schubiger PA (1995) Development of a simple and selective separation of 67Ga from irradiated zinc for use in antibody labeling. Appl Radiat Isot 46:329–336
  • 14. Sheka IS, Chaus IS, Mityureva TT (1996) The chemistry of gallium. Elsevier, Amsterdam
  • 15. Szelecsényi F, Boothe TE, Takács S, Tárkányi F, Tavano E (1998) Evaluated cross-section and thick target yield data bases of Zn+p processes for practical applications.Appl Radiat Isot 49:1005–1032
  • 16. Tárkányi F, Szelecsényi F, Kovács Z, Sudar S (1990) Excitation functions of proton induced nuclear reactions on enriched 66Zn, 67Zn and 68Zn. Radiochim Acta 50;19–24
  • 17. Van der Walt TN, Strelow FWE (1983) Quantitative separation of gallium from other elements by cation-exchange chromatography. Anal Chem 55:212–216
  • 18. Von Falck C, Boerner AR, Galanski M, Knapp WH (2007) Neuroendocrine tumour of the mediastinum: fusion of 18F-FDG and 68Ga-DOTATOC PET/CT data sets demonstrates different degrees of differentiation. Eur J Med Mol Imaging 34:812
  • 19. Weber WA (2005) Use of PET for monitoring cancer therapy and for predicting outcome. Nucl Med 46:983–985
  • 20. Ziegler JF, Biersack JP, Littmark U (2006) The code of SRIM, the stopping and range of ions in mater. IBMResearch, New York, USA
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ6-0025-0057
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