Bis(2-amidophenyl) Diselenides Derived from Amino Acids and Dipeptides: Synthesis, Antiviral and Antimicrobial Activity

• Autorzy: Palus J. , Dąbrowska E. , Piętka-Ottlik M. , Piasecki E. , Młochowski J.
• Języki publikacji: EN

Abstrakty

EN

Synthesis of bis(2-aminophenyl) diselenide 1 derivatives, having amino acids and dipeptides moieties, has been reported. This process has been realized by acylation of both amine groups in 1 us ing N-Boc blocked amino acids 8 in the presence of DCC and HOBT, followed by deprotection to hydrochlorides 9. The free amines 2 have been obtained by removing the protective groups. In the similar way dipeptides 3, 10 and 11 have been prepared. Selected compounds have been tested as potential antiviral, antibacterial and antifungial agents.

Słowa kluczowe

EN

selenium compounds; amino acids; dipeptides; antiviral activity; antimicrobial activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2008
• Tom: Vol. 82, nr 5
• Strony: 1015--1022
• Opis fizyczny: Bibliogr. 11 poz., rys.

Twórcy

autor

Palus J.

autor

Dąbrowska E.

autor

Piętka-Ottlik M.

autor

Piasecki E.

autor

Młochowski J.

• Institute of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland,

Bibliografia

• 1.    Młochowski J., Kloc K., Lisiak R., Potaczek P. and Wójtowicz H., ARCHIVOC, 6, 14 (2007).
• 2.    Mugesh G., du Mont W.-W. and Sies H., Chem. Rev., 101, 2125 (2001).
• 3.    Hwang I.Y. and Elfara A.A., J. Pharmacol. Exp. Ther., 251, 448 (1989).
• 4.    Sies H., Free Rad. Biol. Med, 14, 313 (1993).
• 5.    Hendrickson W.A., Science, 254, 51 (1991).
• 6.  Wójtowicz H., Chojnacka M., Młochowski J., Palus J., Syper L., Hudecova D., Uher M., Piasecki E. and Rybka K., Il Farmaco, 58 (12), 1235 (2003).
• 7.    Fiakpui C.Y. and Knaus E.E., Can. J. Chem., 65, 1224 (1987).
• 8.    Prabhu K.R., Ramesha A.R. and Chandrasekaran M., J. Org. Chem., 60, (6), 1735 (1995).
• 9.    Ye T., Anthony M. and Mc Kervey J., Tetrahedron, 48, (37), 8007 (l 992).
• 10.   Mulier D., Zeltser J., Bitan G. and Gilon C., J. Org Chem., 63, (22), 7763 (1998).
• 11.   Walker E.R., Leung S.Y. and Barret A.G.M., Tetrahedron Lett., 43, 6537 (2005).