1-(2,4-Dinitrophenyl)-5-nitrouracil a Versatile Reagent for the Synthesis of N1-Modified Uracil Derivatives

• Autorzy: Gondela A. , Sroka M. , Walczak K.
• Języki publikacji: EN

Abstrakty

EN

1-(2,4-Dinitrophenyl)-5-nitrouracil has been used as a substrate in reactions with a number of compounds possessing primary amino groups such as: amino alcohols, aminodiols, esters of amino ac ids and benzylamines. As a result of regioselective course of performed reactions the series of 5-nitro-1-substituted uracils were obtained. All newly synthesized compounds were subjected to primary bioactivity as says as inhibitors against Mycobacterium tuberculosis; two of them exhibited inhibition ability.

Słowa kluczowe

EN

5-nitrouracil; aminodiols; ANRORC reaction; acyclic nucleosides; amino acids methyles ters; tuberculosis inhibition

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 12
• Strony: 2143--2149
• Opis fizyczny: Bibliogr. 13 poz., rys.

Twórcy

autor

Gondela A.

autor

Sroka M.

autor

Walczak K.

• Department of Organic Chemistry, Biochemistry and Biotechnology, Silesian University of Technology,Krzywoustego 4, 44-100 Gliwice, Poland Tel. + 4832 237 1792; Fax: [phone],

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