Radiation stability of 125I-brachytherapy sources

• Autorzy: Saxena S. , Ram R. , Dash A. , Joshi P. , Venkatesh M.
• Języki publikacji: EN

Abstrakty

EN

Low energy 125I-brachytherapy sources are used for the treatment of retinoblastoma and many other forms of eye cancer. Such sources were prepared by adsorption of 125I on palladium coated silver rods and were critically evaluated for safety aspects, as per AERB standards. In order to attain low leachability and to facilitate leak free laser encapsulation of sources within titanium capsules of size 0.8 mm (f) ´ 4.75 mm (l), the radioactive source core was coated with polystyrene. With a view to study the radiation stability of such sources over a period of three weeks, both polymer coated radioactive sources and inactive source cores were separately subjected to an integrated gamma dose of ~(17.85 ´ 104) Gy (17.85 MRad), which is the dose expected to be received in three weeks from a source containing ~ 111 MBq of 125I. This was carried out to test their suitability for reuse within such period. SEM pictures of inactive source cores were taken to observe the effect of gamma radiation on palladium coating. Post-irradiation leachability and uniformity of activity of radioactive sources were evaluated and found to be satisfactory. The sources were found to be reusable safely, for repeated brachytherapy procedures over a practically useful time of at least three weeks.

Słowa kluczowe

EN

retinoblastoma; 125 I-brachytherapy sources; radiation stability; SEM; leach rate

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2007
• Tom: Vol. 52, nr 1
• Strony: 13--16
• Opis fizyczny: Bibliogr. 7 poz., rys.

Twórcy

autor

Saxena S.

autor

Ram R.

autor

Dash A.

autor

Joshi P.

autor

Venkatesh M.

• Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India, Tel.: [phone]/0621, Fax: [phone],

Bibliografia

• 1. AERB SS-3 (2001) Testing and classification of sealed radioactive sources, 2nd ed. Atomic Energy Regulatory Board, Mumbai, India
• 2. Finger PT (1997) Radiation therapy for choroidal melanoma. Surv Opthalmol 42:215−232
• 3. Heintz BH, Wallace RE, Hevezi JM (2001) Comparison of I-125 sources used for permanent interstitial implants.Med Phys 28:671−682
• 4. Howell RW (1992) Radiation spectra for Auger-electron emitting radionuclides. Report No 2 of AAPM Nuclear Medicine Task Group No 6. Med Phys 19;6:1371−1383
• 5. Rastogi RC, Sehgal JD, Chandra K, Thomas KT (1969)Final report on investigation of materials and methods for fixation of low and medium level radioactive waste in stable solid media. Bhabha Atomic Research Centre,Mumbai, India
• 6. Saxena SK, Rajurkar Nilima S, Majali MA, Dash A,Venkatesh M (2004) Retardation in leach rate of 125I-brachytherapy sources by polymer coating. In: 15th Annual Conf of Indian Nuclear Society (INSAC-2004)on Nuclear Technology and Societal Needs, Mumbai,India. Poster presentation, S-4/1, pp 1−9 (CD edition)
• 7. Saxena SK, Shanta A, Rajurkar Nilima S, Majali MA (2006) Studies on the production and quality assurance of miniature 125I-radioactive sources suitable for the treatment of ocular and prostate cancer. Appl Radiat Isot 64:441−447