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Abstrakty
A new series of N,S-substituted 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives 12-15, 17, 18 and 20-24 have been synthesized as potential anti-HIV agents. All compounds were screened at the National Cancer Institute (Bethesda, USA) for their in vitro anti-HIV-1 activity, and relationships between structure and anti-HIVactivity are discussed. The prominent compounds with remarkable activity were [5-chloro- 4-methyl-2-(1H-pyrrol-1-ylsulfonyl)phenylthio]acetamide 22 (EC50 = 5.9 _M) and 4-bromophenyl 5-chloro-4-methyl-2-(1H-pyrrol-1-ylsulfonyl)phenylthiomethyl ketone 4-phenylsemicarbazone 24 (EC50 = 5.1 mi M).
Wydawca
Czasopismo
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Tom
Strony
1807--1815
Opis fizyczny
Bibliogr. 21 poz., rys.
Twórcy
autor
autor
- Department of Chemical Technology of Drugs, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland
Bibliografia
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- 7. Brzozowski Z., Acta Polon. Pharm. Drug Res., 55, 49 (1998).
- 8. Brzozowski Z., Acta Polon. Pharm. Drug Res., 55, 473 (1998).
- 9. Neamati N., Mazumder A., Sunder S., Owen J.M., Schultz R.J. and Pommier Y., Antivir. Chem. Chemother., 8,485(1997).
- 10. Nicklaus M.C., Neamati N., Hong H., Mazunder A., Sunder S., Chen J., Milne G., and Pommier Y., J. Med. Chem., 40, 920 (1997).
- ll. Kuo Ch.L., Assefa H., Kamath S., Brzozowski Z., Sławiński J., Sączewski F., Buolamwini J.K. and Neamati N., J. Med. Chem., 47, 385 (2004).
- 12. Neamati N., Mazumder A., Zhao H., Sunder S., Burke T.R., Schultz R.J. and Pommier Y, Antimicrob. Agents Chemother., 41, 385 (1997).
- 13. Neamati N., Lin Z., Karki R.G., Orr A., Cowanasge K., Strumberg D., Pais G.C., Voigt J.H., Niclaus M.C., Winslow H.E., Zhao H., Turpin J.A., Yi J., Skałka A.M., Burke T. R. and Pommier V, J. Med. Chem., 45, 5661(2002).
- 14. Pannecouque C., Pluymers W., Van Maele B., Tetz V., Cherepanov P., De Clerca E., Witvrouw M. and DebyserZ., Curr. Biol, 12, 1169 (2002).
- 15. Brzozowski Z., Sączewski F., SanchezT., Kuo Ch.L., Gdaniec M. and Neamati N., Bioorg. Med. Chem., 12, 3663 (2003).
- 16. Brzozowski Z., Sączewski F. and Neamati N., Bioorg. Med. Chem., 14, 2985 (2006).
- 17. Brzozowski Z. and Sławiński J., Acta Polon. Pharm., 41, 133 (1984).
- 18. Pomarnacka E., Brzozowski Z., Filczewski M., Szymańska-Kosmala M. and Olędzka K., Acta Polon. Pharm., 42, 501 (1985).
- 19. Pomarnacka E., Sci. Pharm., 55, 121 (1987).
- 20. Brzozowski Z., Acta Polon. Pharm., 44, 484 (1987).
- 21. Wieslow O.W., Kiser R., Fine D., Bader J., Shoemaker R.H. and Boyd M.R., J. Natl. Cancer. Inst., 81, 577(1989).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ6-0007-0055