Synthesis of N,S-Substituted 4-Chloro-2-mercapto-5-methylbenzenesulfonamide Derivatives as Potential Anti-HIV Agents

• Autorzy: Brzozowski Z. , Sławiński J.
• Języki publikacji: EN

Abstrakty

EN

A new series of N,S-substituted 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives 12-15, 17, 18 and 20-24 have been synthesized as potential anti-HIV agents. All compounds were screened at the National Cancer Institute (Bethesda, USA) for their in vitro anti-HIV-1 activity, and relationships between structure and anti-HIVactivity are discussed. The prominent compounds with remarkable activity were [5-chloro- 4-methyl-2-(1H-pyrrol-1-ylsulfonyl)phenylthio]acetamide 22 (EC50 = 5.9 _M) and 4-bromophenyl 5-chloro-4-methyl-2-(1H-pyrrol-1-ylsulfonyl)phenylthiomethyl ketone 4-phenylsemicarbazone 24 (EC50 = 5.1 mi M).

Słowa kluczowe

EN

N,S-substituted 4-chloro-2-mercapto-5-methylbenzenesulfonamides; synthesis; anti-HIV activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 11
• Strony: 1807--1815
• Opis fizyczny: Bibliogr. 21 poz., rys.

Twórcy

autor

Brzozowski Z.

autor

Sławiński J.

• Department of Chemical Technology of Drugs, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland

Bibliografia

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