Assessment of Metabolite Concentrations Changes in Rat Brain after Intravenous CDPcholine Injection Using Magnetic Resonance Spectroscopy in vivo

• Autorzy: Kulinowski P. , Labak M. , Majcher K. , Herbik A. , Grieb P. , Jasiński A.
• Konferencja: 1st Symp. on NMR in Chemistry, Biology and Medicine; 8-10 Semptember, Warsaw, Poland. Issue dedicated to honour Prof. Witanowski
• Języki publikacji: EN

Abstrakty

EN

CDPcholine (citicoline, CDPCho) shows beneficial effects in various Central Nervous System (CNS) injury models and neurodegenerative diseases. Previous studies demonstrate conflictingMagnetic Resonance Spectroscopy (MRS) reports regarding the impact of different choline-containing compounds and its doses on brain metabolites. This preliminary study was designed to evaluate concentration changes of brain MR-visible metabolites following intravenous CDPCholine. Twelve healthy rats treated with CDPCholine in three subsequent doses of 1gram/kg eachwere examined using 1Hand 31P MRS in vivo. Following intravenous CDPCholine administration there was a statistically significant increase of the Cho/Cr ratio after first CDPCholine injection. The evidence of CDPcholine influence on brain metabolites has been shown.

Słowa kluczowe

EN

CDP-choline; choline; cerebral metabolism; Magnetic Resonance Spectroscopy

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 7
• Strony: 1125--1132
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Kulinowski P.

autor

Labak M.

autor

Majcher K.

autor

Herbik A.

autor

Grieb P.

autor

Jasiński A.

• 1H. Niewodniczański Institute of Nuclear Physics PAS, Radzikowskiego 152, 31-342 Kraków, Poland

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