Production of [18F] fluoride with a high-current two layer spherical gold target

• Autorzy: Mirzaii M. , Afarideh H. , Hadji-Saeid S. , Aslani G. , Ensaf M.
• Języki publikacji: EN

Abstrakty

EN

A new automated target for high yield production of aqueous [18F] fluoride at high beam currents has been constructed for a cyclotron at NRCAM in Karaj (Cyclone 30). It consists of one small golden sphere inside another target chamber, mounted into a special holder, which provides rapid cooling by water flow around and inside the sphere. The target is irradiated with 28 MeV protons. The incident energy on the target chamber is 18 MeV. This target is operated without external overpressure and has been tested for beam currents up to 60 ěA. The measured target yield is 80% of the theoretically calculated yield of 18F, which is used for the synthesis of [18F] 2-fluoro-2-deoxy-D-glucose.

Słowa kluczowe

EN

water target; [18F] fluorine; FDG; PET; high current

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2004
• Tom: Vol. 49, nr 1
• Strony: 23--27
• Opis fizyczny: Bibliogr. 23 poz., rys.

Twórcy

autor

Mirzaii M.

• Nuclear Research Center for Agriculture and Medicine (NRCAM), P. O. Box 31585-4395 Karaj, Iran
• Amir Kabir University of Technology, P. O. Box 15875-4413 Tehran, Iran, Tel.: [phone], Fax: [phone]

autor

Afarideh H.

• Nuclear Research Center for Agriculture and Medicine (NRCAM), P. O. Box 31585-4395 Karaj, Iran

autor

Hadji-Saeid S.

• Nuclear Research Center for Agriculture and Medicine (NRCAM), P. O. Box 31585-4395 Karaj, Iran

autor

Aslani G.

• Nuclear Research Center for Agriculture and Medicine (NRCAM), P. O. Box 31585-4395 Karaj, Iran

autor

Ensaf M.

• Nuclear Research Center for Agriculture and Medicine (NRCAM), P. O. Box 31585-4395 Karaj, Iran

Bibliografia

• 1. Becker DW, Erbe D (1998) A new high current spherical target design for 18O(p,n)18F with 18 MeV protons. In: Proc of the 7th Workshop on Targetry and Target Chemistry, Heidelberg 1997, pp 268−269
• 2. Berridge MS, Kjellstrom R (1988) Fluorine-18 production: new designs for O-18 water targets. J Labelled Compd Radiopharm 26:188−189
• 3. Berridge MS, Tewson TJ (1986) Effects of target design on the production and utilization of [18F] fluoride from [18O]water. J Labelled Compd Radiopharm 23:1177−1178
• 4. DeJesus OT, Martin JA, Yasillo NJ, Gatley SJ, Cooper MD (1986) [18F] Fluoride from a small cyclotron for the routine synthesis of [18F] 2-fluoro-2-deoxy-D-glucose. Appl Radiat Isot 37:397−401
• 5. Helmeke HJ, Harms T, Knapp WH (2001) A water target with beam sweep for routine fluoride-18 production. Appl Radiat Isot 54:753−759
• 6. Hess E, Blessing G, Coenen HH, Qaim SM (2000) Improved target system for production of high purity [18F] fluoride via the 18O(p,n)18F reaction. Appl Radiat Isot 52:1431−1440
• 7. http://www.kulite.co.uk/product.htm − Kulite measuring pressure sensor (type: XTM-190 0−35 bar)
• 8. Huszar I, Weinreich R (1985) Production of 18F with an 18O-enriched water target. J Radioanal Nucl Chem Lett 93:349−354
• 9. Iwata R, Ido T, Brady F, Takahashi T, Ujiie A (1987) [18F] fluoride production with a circulating [18O] water target. Appl Radiat Isot 38:979−984
• 10. Keikonen J, Fontell A, Kaireto A-L (1986) Effective small volume [18O] water target for the production of [18F] fluoride. Appl Radiat Isot 37:631−632
• 11. Kilbourn MR, Hood JT, Welch MJ (1984) A simple 18O water target for 18F production. Int J Appl Radiat Isot 35:599−602
• 12. Lepera GCE, Dembowski B (1997) Production of [18F] fluoride with a high-pressure disposable [18O] water target. Appl Radiat Isot 48:613−617
• 13. Mulholland GK, Hichwa RD, Kilbourn MR, Moskwa J (1989) A reliable water target for fluorine-18 production at high beam currents. J Labelled Compd Radiopharm 26:192−193
• 14. Nickles RJ, Gatley SJ, Votaw JR, Kornguth ML (1986) Production of reactive fluorine-18. Appl Radiat Isot 37:649−661
• 15. Qaim SM, Blessing G, Stocklin G (1987) Routinely used cyclotron targets for radioisotope production at KFA Jülich. In: Proc of the 2nd Workshop on Targetry and Target Chemistry, Heidelberg 1985, pp 50−57
• 16. Roberts AD, Daniel LC, Nickles RJ (1995) A high power target for the production of [18F] fluoride. Nucl Instrum Meth Phys Res B 99:797−799
• 17. Solin O, Bergman J, Haaparanta M, Reisssel A (1988) Production of 18F from water targets. Specific radioactivity and anionic contaminants. Int J Appl Radiat Isot39:1065−1071
• 18. Steinbach J, Guenther K, Loesel E et al. (1990) Temperature course in small volume [18O] water targets for [18F] F−production. Appl Radiat Isot 41:753−756
• 19. Van Brocklin H, Padgett H, Alvord C, Schimdt D, Bida GT (1995) High pressure H2 18O target for the production of [18F] fluoride ion. In: Emran AM (ed.) Chemists’ view of imaging centers. Plenum Press, New York, pp 329−338
• 20. Vogt M, Huszar I, Argentini M, Oehninger H, Weinreich R (1986) Improved production of [18F] fluoride via the [18O]H2O(p,n) 18F reaction for no-carrier-added nucleophilic syntheses. Appl Radiat Isot 37:448−449
• 21. Wieland BW, Wolf AP (1983) Large-scale production and recovery of aqueous [18F] fluoride using proton bombardment of small-volume [18O] water target. J Nucl Med 24:122−127
• 22. Zeisler SK, Becker DW, Pavan RA, Moschel R, Ruhle H (2000) A water-cooled spherical niobium target for the production of [18F] fluoride. Appl Radiat Isot 53:449−453
• 23. Ziegler JF, Biersack JP, Littmark U (2000) The code of SRIM − the Stopping and Range of Ions in Matter, January 1, 2000, version 2000.xx