A convenient method for synthesis of 11-[14C]-loxapine

• Autorzy: Saemian N. , Shirvani G. , Matloubi H.
• Języki publikacji: EN

Abstrakty

EN

8-Chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f][1,4]oxazepine labeled with carbon-14 in 11-position has been synthesized as part of a 5-step sequence from potassium [14C] cyanide.

Słowa kluczowe

EN

dibenzoxazepine; carbon-14; microwave heating

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2005
• Tom: Vol. 50, nr 4
• Strony: 139--141
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Saemian N.

• Chemical Division, Nuclear Research Center, AEOI, P. O. Box 11365-3486, Tehran, Iran, Tel.: [phone], Fax: [phone]

autor

Shirvani G.

• Chemical Division, Nuclear Research Center, AEOI, P. O. Box 11365-3486, Tehran, Iran, Tel.: [phone], Fax: [phone]

autor

Matloubi H.

• Chemical Division, Nuclear Research Center, AEOI, P. O. Box 11365-3486, Tehran, Iran, Tel.: [phone], Fax: [phone]

Bibliografia

• 1. Katritzky AR, Pilariski B, Urogdi L (1989) Efficient conversion of nitrile to amides with hydrogen peroxide in dimethyl sulfoxide. Synthesis: 949−950.
• 2. Klunder JM, Hargraue KD, West MA et al. (1992) Tricyclic pyridobenzoxazepinones and dibenzoxaze-pinones. J Med Chem 35:1887−1897.
• 3. Li F, Wang Q, Ding Z, Tao G (2003) Microwave-assisted synthesis of diaryl ethers without catalyst. Org Lett 5:2169−2171.
• 4. Liegeois JFF, Bruhwyler J, Damas J, Nguyen TP, Chleide EMG (1993) New pyrido benzodiazepine derivatives as potential anti psychotics: synthesis and neurochemical study. J Med Chem 36:2107−2114.
• 5. Liegeois JFF, Rogister FA, Bruhwyler J et al. (1994) Pyrido benzoxazepine and pyrido benzothiazepine derivative as potential central nervous system agents: synthesis and neuro chemical study. J Med Chem 37:519−525.
• 6. Matloubi H, Ghandi M, Saemian N (2001) Synthesis of a carbon-14 analogue of 8-chloro-11-(4-methyl-1-piperazinyl)-11-[14C]-dibenz[b,f][1,4]oxazepine. Appl Radiat Isot 57:501−504.
• 7. Matloubi H, Ghandi M, Zarrindast MR, Saemian N (2001) Modifide synthesis of 11-[14C]-clozapine. Appl Radiat Isot 55:789−791.
• 8. Perry CW, Burger W, Dlaney CM (1978) An improved of preparation of potassium [14C] cyanide. J Labelled Compd Radiopharm 16:645−649.
• 9. Seidel D, Brehmer D, Schoof Y, Weinber U, Niewohner U, Nowakowski M (2003) Synthesis of [14C]-labelled vardenafil hydrochloride and metabolites. J Labelled Compd Radiopharm 46:1019−1032.
• 10. Steiner G, Franke A, Hadicke E et al. (1986) Tricyclic epines novel (E)-and(Z)-11H-dibenzo[b,e]azepines as potential central system agents, variations of the basic side chain. J Med Chem 29:1877−1888.