An approach to the preparation of iodine-125 seed-type sources

• Autorzy: Cieszykowska I. , Piasecki A. , Mielcarski M.
• Języki publikacji: EN

Abstrakty

EN

The deposition of iodine-125 on silver bars to be sealed in titanium capsules as seed-type sources for brachytherapy was studied. For this purpose, a method of internal electrolysis was applied. The cell consisted of a silver anode contained in a Pt crucible serving as cathode. The plating solution contained sodium iodide-125 and sodium hydroxide. The yield of iodine-125 deposition for carrier-containing and carrier-free electrolyte solutions was determined. The deposition on uncutted Ag wires and on those cutted into 3 mm long bars was investigated. The influence of visible light on the coating process was examined. The leachability of iodine-125 from the silver wires as well as the activity distribution on the wires was measured. The obtained results indicate that the silver wire should be first coated with iodine-125 and then cutted into 3 mm long pieces. Based on this observation, a device for a batch-type procedure of manufacturing I-125 plated silver bars was designed and made. A design for simultaneous cutting and positioning of the activity-carrying bars into the titanium capsules is presented. This arrangement has been built and tested in trials. The tests confirmed that contamination of the source capsules can be minimized. Laser weldings of the titanium capsules were performed and the cross section of the welds examined by the use of an optical microscope.

Słowa kluczowe

EN

iodine-125 sealed sources; seed-type sources; brachytherapy sources

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2005
• Tom: Vol. 50, nr 1
• Strony: 17--22
• Opis fizyczny: Bibliogr. 15 poz., rys.

Twórcy

autor

Cieszykowska I.

• Radioisotope Centre POLATOM, 05-400 Otwock/Świerk, Poland, Tel.: [phone], Fax: [phone]

autor

Piasecki A.

• Radioisotope Centre POLATOM, 05-400 Otwock/Świerk, Poland, Tel.: [phone], Fax: [phone]

autor

Mielcarski M.

• Radioisotope Centre POLATOM, 05-400 Otwock/Świerk, Poland, Tel.: [phone], Fax: [phone]

Bibliografia

• 1. Baker M, Bass GA, Woods MJ (2002) Calibration of the NPL secondary standard radionuclide calibrator for 125I seeds used for prostate brachytherapy. Appl Radiat Isot 56:321−325.
• 2. ISO (1992) Radiation protection-sealed radioactive sources-leakage test methods ISO 9978. International Organisation for Standardisation, Geneva, Switzerland.
• 3. Kuznetsov RA, Pakhomov AN, Radchenko VM et al.(2003) Development of Pd-103 reactor production technology and technology for production of Pd seeds core by electrochemical plating. In: Proc of the 2nd Research Co-ordination Meeting on Development of Radioactive Sources for Emerging Therapeutic and Industrial Application, Headquaters, 20−24 October 2003, Vienna, Austria. Technical Report. IAEA, Vienna.
• 4. Manolkar RB, Sane SU, Pillai KT, Majali MA (2003) Comparison of methods for preparation of 125I brachytherapy sources cores for the treatment of eye cancer. Appl Radiat Isot 59:145−150.
• 5. Mathew C, Majali MA, Balakrishnan SA (2002) A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer. Appl Radiat Isot 57:359−367.
• 6. Meigooni AS, Yoe-Sein MM, Al-Otoom AY, Sowards KT (2002) Determination of the dosimetric characteristics of InterSource 125I brachytherapy source. Appl Radiat Isot 56:589−599.
• 7. Mielcarski M, Puchalska I (2002) Deposition of Ru-106 and I-125 on silver by internal electrolysis. Nukleonika 47;2:83−86.
• 8. Milazzo G (1963) Electrochemistry. Elsevier, Amsterdam.
• 9. Nath R, Yue N (2001) Dosimetric characterization of a newly designed encapsulated interstitial brachytherapy source of iodine-125 – model LS-1 Brachyseed™. Appl Radiat Isot 55:813−821.
• 10. Puchalska I, Mielcarski M (2003) Seed-less iodine-125 ophthalmic applicator. Appl Radiat Isot 58:15−20.
• 11. Rivard MJ (2002) Comprehensive Monte Carlo calcu-lations of AAPM Task Group Report No 43 dosimetry parameters for the Model 3500 I-Plant 125I brachytherapy source. Appl Radiat Isot 57:381−389.
• 12. Sowards KT, Meigooni AS (2002) A Monte Carlo evaluation of the dosimetric characteristics of theBest®Model 2301 125I brachytherapy source. Appl Radiat Isot 57:327−333.
• 13. Wallace RE (2002) Model 3500 125I brachytherapy source dosimetric characterization. Appl Radiat Isot 56:581−587.
• 14. Wang R, Sloboda RS (2002) Monte Carlo dose parameters of the BrachySeed model LS-1 125I brachytherapy source. Appl Radiat Isot 56:805−813.
• 15. Wilson W (1946) Silver iodide (chapter 17). In: Mellor JW (ed) Comprehensive treatise on inorganic and theoretical chemistry. Longmans, Green and Co.,London−New York−Toronto, p 431.