Synthesis of the Potential Mannosidase Inhibitor via 1,3-Dipolar Cycloaddition Involving Cyclic Nitrone and Unsaturated Chiral gamma-Lactone

• Autorzy: Stecko S. , Paśniczek , K. , Jurczak M. , Solecka J. , Chmielewski M.
• Języki publikacji: EN

Abstrakty

EN

The 1,3-dipolar cycloaddition of cyclic nitrone derived from tartaric acid with (S)-5-hydroxymethyl-2(5H)-furanone leads to a single adduct which was transformed into 1,2,6,7-tetrahydroxy-2-hydroxymethyl-indolizidine via reaction sequence involving protection of the hydroxymethyl group, reduction of the lactone moiety, protection of the resulting diol, and the N-O hydrogenolysis followed by the intramolecular alkylation of the nitrogen atom.

Słowa kluczowe

EN

nitrone; iminosugars; 1,3-dipolar cycloaddition

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2009
• Tom: Vol. 83, nr 2
• Strony: 237--243
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Stecko S.

autor

Paśniczek , K.

autor

Jurczak M.

autor

Solecka J.

autor

Chmielewski M.

• Institute of Organic Chemistry of the Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland,

Bibliografia

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