Designing and Synthesis of a Highly Symmetric and Conjugated Macrocyclic Knoevenagel Schiff Base Model Ligand and Its Transition Metal Complexes : Spectral Characterization, Antimicrobial Activity and DNA Cleavage Studies

• Autorzy: Raman N. , Parameswari S.
• Języki publikacji: EN

Abstrakty

EN

A novel macrocyclic Knoevenagel Schiff base ligand has been designed and synthesized using 3-cinnamalideneacetoacetanilide and 4,4'-diaminodiphenylmethane. It acts as a tetradentate and strongly conjugated to form acationic solid complex with CuCl2/NiCl2/CoCl2/ZnCl2/MnCl2/CdCl2/HgCl2/VOSO4. The formed ligand and the complexes were characterized by usual spectral and analytical techniques. All the synthesized complexes were characterized by microanalytical data, magnetic susceptibility measurements, IR, UV-Vis, 1H-NMR, ESR and mass spectral techniques. They exhibit square-planar geometry except oxovanadium complex, which has square-pyramidal geometry. The electrolytic behaviour and monomeric nature of the com plexes were confirmed from their conductance data and magnetic susceptibility values. The X-band ESR spectra of Cu(II) and VO(IV) complexes in DMSO at 300 and 77 K were recorded and their salient features are reported. The in vitro antimicrobial activi ies of the investigated compounds were tested against few microorganisms by well-diffusion technique. It was found that the metal complexes have higher activity than the ligand. The cleavage activity of all the complexes was examined on CT-DNA using gel electro phoresis experiment in the presence of H2O2. From the data, it was found that oxovanadium, zinc and manganese complexes cleave DNA through redox chemistry.

Słowa kluczowe

EN

Knoevenagel Schiff base; metal complexes; antimicrobial activity; DNA

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2008
• Tom: Vol. 82, nr 7
• Strony: 1331--1334
• Opis fizyczny: Bibliogr. 25 poz., rys.

Twórcy

autor

Raman N.

autor

Parameswari S.

• Department of Chemistry, VHNSN College, Virudhunagar-626 001, India,

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