Galanin and Its Analogues Modified in Position 14: Chemical Synthesis and Biological Activity

• Autorzy: Ruczyński J. , Szyk A. , Konstański Z. , Korolkiewicz R. , Rekowski P.
• Języki publikacji: EN

Abstrakty

EN

In search of a specific galanin receptor antagonist, 15-amino-acid-residue analogues of porcine galanin modified in position 14 were synthesized and their activity was studied on isolated rat smooth muscles. It was shown that all galanin analogues contracted rat gastric fundus strips in a concentration-dependent manner with significantly increased activities as compared to GAL(1-15)NH2. The results suggest that position 14 in the amino acid sequence of GAL(1-15)NH2 is important for the biological activity.

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2000
• Tom: Vol. 74, nr 10
• Strony: 1375--1384
• Opis fizyczny: Bibliogr. 45 poz., rys.

Twórcy

autor

Ruczyński J.

autor

Szyk A.

autor

Konstański Z.

autor

Korolkiewicz R.

autor

Rekowski P.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland