A Mild and Convenient Oxidation of H-Phosphinic Acids

• Autorzy: Berlicki Ł. , Mucha A. , Kafarski P.
• Języki publikacji: EN

Abstrakty

EN

A new mild and convenient method of oxidation of H-phosphinic to the corresponding phosphonic acids was developed. Conversion of H-phosphinic acids into trivalent trimethylsilyl esters using hexamethyldisilazane, followed by their oxidation with air and subsequent methanolysis al lowed obtaining the final compounds in good to excellent yields. The methodology was proved to be particularly useful for N-benzyloxycarbonyl alfa- aminophosphinic acids. The scope and limitations of the reaction were additionally tested using a variety of both free and protected amino- and hydroxy phosphinates as substrates.

Słowa kluczowe

EN

aminophosphinate; aminophosphonate; oxidation

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 11
• Strony: 1959--1962
• Opis fizyczny: Bibliogr. 30 poz., rys.

Twórcy

autor

Berlicki Ł.

autor

Mucha A.

autor

Kafarski P.

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland,

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