Synthesis of Deuterium, Tritium and 14-Carbon Labelled Isotopomers of L-DOPA

• Autorzy: Kozłowska M. , Kańska M.
• Języki publikacji: EN

Abstrakty

EN

The synthesis of five isotopomers of L-DOPAlabelled selectivelywith deuterium, tritium and 14C is reported. The isotopomers of L-tyrosine, the intermediate substrates for this synthesis, were obtained using chemical and enzymatic methods. Selectively labelled isotopomers of L-tyrosine were hydroxylated respectively to [3R-3H]-L, [5-2H]-L, [2 ,6 -2H2]-L, doubly labelled [5-2H/3H]-L, and [1-14C]-L-DOPA using activity of enzyme tyrosine (EC 1.14.18.1) isolated from mushrooms.

Słowa kluczowe

EN

carbon-14; enzyme; deuterium; DOPA; tritium

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 10
• Strony: 1763--1763
• Opis fizyczny: –1769, Bibliogr. 39 poz., rys.

Twórcy

autor

Kozłowska M.

autor

Kańska M.

• Department of Chemistry, University of Warsaw, Pasteur 1 Str., 02-093 Warsaw, Poland,

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