Synthesis of New 2-Aminobenzimidazole Derivatives. Part 4. Reactions of 2-Arylideneaminobenzimidazole with Selected -Ketoesters

• Autorzy: Nawrocka W. P. , Kowalska M. W. , Sztuba B. , Dryś A. , Wietrzyk J. , Filip B.
• Języki publikacji: EN

Abstrakty

EN

Schiff bases 2–6 obtained from 2-aminobenzimidazole 1 with p-(N,N-diethylamino)-, p-chloro-, p-bromo-, 2,4-dimethoxy-, and 3,4-dimethoxybenzaldehyde were subjected to the reaction with 1,3-ketoester: methyl-, ethyl-, benzyl-, and t-butylacetoacetate to form derivatives of pyrimido[1,2-a]benzimidazole 7–23. 1H NMR spectra recorded for the compounds 20–23 in DMSO solution indicate the presence of two conformational forms. Compounds 2, 7–23 were examined for their antiproliferative activity in vitro against the cells of human lung cancer cell lines A549.

Słowa kluczowe

EN

2-arylideneaminobenzimidazole; pyrimido[1,2-a]benzimidazole; IR; 1H NMR and MS spectra

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 10
• Strony: 1753--1753
• Opis fizyczny: –1761, Bibliogr. 33 poz., rys.

Twórcy

autor

Nawrocka W. P.

autor

Kowalska M. W.

autor

Sztuba B.

autor

Dryś A.

autor

Wietrzyk J.

autor

Filip B.

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