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Abstrakty
The synthesis of S-(5-chloro-4-methyl-2-sulfamoylphenyl) N-(phenylsulfonyl)benzothiohydrazonates 4a–k is described. The compounds 4b–f and 4j–k were screened at the US National Cancer Institute for their in vitro activities against a panel of 53–57 human tumor cell lines and relationship between structure and antitumor activity is discussed. The compound 4b was inactive, whereas the remaining compounds exhibited fairly high or reasonable activity (GI50 = 8.12–24.9 miM) against one or more human tumor cell lines.
Wydawca
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Tom
Strony
1433--1440
Opis fizyczny
Bibliogr. 17 poz., rys.
Twórcy
autor
autor
- Department of Chemical Technology of Drugs, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416Gdańsk, Poland, jaroslaw@amg.gda.pl
Bibliografia
- 1. Casini A., Scozzafava A., Mastrolorenzo A. and Supuran C.T., Curr. CancerDrug Targets, 2,55 (2002).
- 2. Scozzafava A., Casini A. and Supuran C.T., Curr. Med. Chem., 9, 1167 (2002).
- 3. Supuran C.T., Casini A. and Scozzafava A., Med. Res. Rev., 23, 535 (2003).
- 4. Scozzafava A., Owa T., Mastrolorenzo A. and Supuran C.T., Curr. Med. Chem., 10, 925 (2003).
- 5. Owa T. and Nagasu T., Exp. Opin. Ther. Patents, 10, 1725 (2000).
- 6. Owa T., Yoshino H., Okauchi T., Yoshimatsu K., Ozawa Y, Sugi N.H., Nagasu T., Koyanagi N. and Kitoch K., J. Med. Chem., 42, 3789 (1999).
- 7. Sławiński J. and Gdaniec M., Eur. J. Med. Chem., 40, 377 (2005).
- 8. Sławiński J. and Brzozowski Z., Eur. J. Med. Chem., 41, 1180 (2006).
- 9. Sławiński J., Eur. J. Med. Chem., 39, 179 (2004).
- 10. Brzozowski Z. and Sławiński J., Acta Polon. Pharm., 41,133 (l984).
- 11. Ito S., Tanaka Y. and Katehi A., Buli. Chem. Soc. Jpn., 53, 2007 (1980).
- 12. Kustova T.R and Kuritsyn L.V, Russ. J. Gen. Chem., 70, 459 (2000).
- 13. Bernardi F., Csizmadia I.G. and Mangini A., Organie Sulfur Chemistry, S. Oae, Ed., Elsevier, Amsterdam, 1985, p. 11.
- 14. Exner O. and Janak R, Collect. Czech. Chem. Commun., 40, 2510 (1975).
- 15. Boyd M.R., Am. Assoc. Cancer Res., 30, 652 (1989).
- 16. Monks A.P., Scudiero D.A., Skehan R, Shoemaker R., Poull K. D., Vistica D., Hose C., Langley J„ Cronise R, Vaigro-Wolff A., Gray-Goodrich M., Cambell H., Mayo J. and Boyd M., J. Natl Cancer Inst., 83, 757(1991).
- 17. Weinstein J.N., Myers T.G., O'Connor RM., Friend S.H., Fornance A J., Jr., Kohn K. W., Fojo T, Bates S.E., Rubinstein L.V., Anderson N.L., Buolamwini J.K., van Osdol W.W., Monks A.R, Scudiero D.A., Sausiville E.A., Zaharevitz D. W., Bunow B., Viswanadhan V.N., Johnson G.S., Wittes R.E. and Paull K.D., Science, 275, 343 (1997).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ5-0014-0077