Studies on the Interaction of Transition Metal Complexes of the Schiff Base Derived from Anthranilic Acid and Acetoacetanilide with DNA

• Autorzy: Raman N. , Rajasekaran K.
• Języki publikacji: EN

Abstrakty

EN

Four neutral complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been prepared with a new tridentate Schiff base (HL) derived from anthranilic acid and acetoacetanilide. The analytical data show that themetal to ligand ratio is 1:2. The structural features have been determined from IR, UV-Vis, 1H-NMR, ESR and mass spectral data. All the complexes exhibit octahedral geometry around the central metal ion. Their low electrical conductance values support their neutral nature. The magnetic moment data provide evidence for the monomeric nature of the complexes. Absorption experiments have been carried out on the interaction of the complexes with calf thymus DNA (CT-DNA). The results suggest that all the complexes can bind to CT-DNA by intercalation between chromophore and DNAbase pairs. An electrochemical study of the copper complex reveals that it prefers to bind to DNA in the Cu(II) rather than the Cu(I) oxidation state. The nucleolytic cleavage activity of all the complexes was examined on CT-DNA by using a gel electrophoresis experiment in the presence and absence of oxidant, H2O2. In the absence of the oxidant, a less discernible DNAcleavage was observed, whereas in the presence of the oxidant, all complexes showed enhanced nuclease activity.

Słowa kluczowe

EN

Schiff base; anthranilic acid; acetoacetanilide; CT-DNA; nuclease activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2007
• Tom: Vol. 81, nr 2
• Strony: 149--159
• Opis fizyczny: Bibliogr. 33 poz., rys.

Twórcy

autor

Raman N.

autor

Rajasekaran K.

• Department of Chemistry, VHNSN College, Virudhunagar-626 001, India

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