Influence of protonation on the stability of disulfide radicals

• Autorzy: Berges J. , Fuster F. , Silvi B. , Jacquot J. , Houee-Levin Ch.
• Konferencja: Reactive Intermediates in Sulfur Chemistry Workshop dedicated to Professor Klaus-Dieter Asmus on His 60th birthday August 23-26, 1998, Poznan, Poland
• Języki publikacji: EN

Abstrakty

EN

The ease of disulfide bond cleavage in peptides and proteins is evaluated by an experimental method (one-electron reduction by COOź- radicals and measurement of the chain length) and two theoretical approaches based on quantum chemistry and topology. All results agree to show acidcatalysis of this bond opening. The disulfide bond in the radical state is weakened by protonation.

Słowa kluczowe

EN

ab initio calculations; disulfide radicals; gamma radiolysis; topology of the Electron Localization Functions

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2000
• Tom: Vol. 45, nr 1
• Strony: 23--29
• Opis fizyczny: Bibliogr. 34 poz., rys.

Twórcy

autor

Berges J.

autor

Fuster F.

autor

Silvi B.

autor

Jacquot J.

autor

Houee-Levin Ch.

• Laboratoire de Chimie Theorique UMR 7616, Universite Paris VI, 4, place Jussieu 75005 Paris, France