Intramolecular transformation of thiyl radicals to a-aminoalkyl radicals: ab initio calculations on homocystein

• Autorzy: Chhun S. , Berges J. , Bleton V. , Abedinzadeh Z.
• Konferencja: Reactive Intermediates in Sulfur Chemistry Workshop dedicated to Professor Klaus-Dieter Asmus on His 60th birthday August 23-26, 1998, Poznan, Poland
• Języki publikacji: EN

Abstrakty

EN

One-electron oxidation of thiols by oxidizing radicals leads to the formation of thiyl and carbon-centered radicals. It has been shown experimentally that in the absence of oxygen, the thiyl radicals derived from certain thiols of biological interest such a glutathione, cysteine and homocysteine decay rapidly by intramolecular rearrangement reactions into the carbon-centered radical. In the present work we have investigated theoretically the structure and the stability of thiyl and carbon-centred radicals of homocystein in order to check the possibility of this rearrangement.

Słowa kluczowe

EN

thiols; carbon centred radicals; ab initio calculations

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2000
• Tom: Vol. 45, nr 1
• Strony: 19--22
• Opis fizyczny: Bibliogr. 40 poz., rys.

Twórcy

autor

Chhun S.

autor

Berges J.

autor

Bleton V.

autor

Abedinzadeh Z.

• Laboratoire de Chimie Theorique, UMR 7616 CNRS, Universite P. et M. Curie, 4 place Jussieu 75230, Paris Cedex, France