Speciation and Spectra of Bromokojatoiron(III) Complexes in Aqueous Solutions

• Autorzy: Šima J. , Šípoš R. , Izakovic M. , Valigura D. , Tarapeík P.
• Języki publikacji: EN

Abstrakty

EN

The formation of iron(III) complexeswith chelating bromokojate anions L– was investigated in aqueous solutions as a function of the pH and c(Fe3+) : c(HL) molar ratio. Stability constants of the complexes [FeL(H2O)4]2+, [FeL(H2 O)3(OH)]+, [FeL2 (H2O)2]+, [FeL2(H2O)(OH)] and [FeL2(OH)2]– were determined by the evaluation of UV-VIS spectral data. Based on the stability constants, distribution of the above complexes, [Fe(H2O)6]3+, and [Fe(H2O)5(OH)]2+ in solutions of various composition were calculated. The paper indicates a compatibility of the used data treatment and that not taking hydroxo complexes into account. Properties of the investigated bromokojic acid and its iron(III) complexes are compared to those required for therapeutic application as alternative iron chelators.

Słowa kluczowe

EN

stability constants; speciation; iron (III) complexes; bromokojic acid

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 12
• Strony: 1991--1999
• Opis fizyczny: Bibliogr. 24 poz., rys.

Twórcy

autor

Šima J.

autor

Šípoš R.

autor

Izakovic M.

autor

Valigura D.

autor

Tarapeík P.

• Department of Inorganic Chemistry, 2 Department of Analytical Chemistry, Slovak Technical University, Radlinského 9, 812 37 Bratislava, Slovakia

Bibliografia

• 1. Wei C.I., Huang T.S., Femando S.Y. and Chung K.T., Toxicol. Lett., 59, 213 (1991).
• 2. Usui K., Fujihira S. and Baba N., Meiji Daigaku Nogakubu Kenkyu Hokoku, 121,15 (2000).
• 3. Luo X. and Liang Y., Faming Zhuanli Shenąuig Gongkai Shuomingshu, CN l, 228, 300 (2000).
• 4. Okabe T. and Suzuki M., Jpn Kokai Tokkyo Koho JP 2000 290,123.
• 5. Avaux D.R. and Laugier J.-P., Eur. Pat. Appl. EP l, 027, 878 (2000).
• 6. Zecchino J., Knight E.A. and Castillo-Bucci C., U.S. Patent, 6, 497, 887 (December 24, 2002).
• 7. Chang S-Y, Kim J-Y, Kim J-H. and Yun S-Y, U.S. Patent, 6, 689, 344 (February 10, 2004).
• 8. Šima J., Coord. Chem. Rev., 159, 195 (1997).
• 9. Bransova J., Brtko J. and Uher M., Slovak Patent SK 279, 726 (1999).
• 10. Mabeza G.F., Biemba G. and Gordeuk G., Acta Haematologica, 95, 78 (1996).
• 11. Hershko C., Clin. Haematol., 7, 965 (1994).
• 12. Breslow R., Belvedere S., Gershell L. and Leung D., Pure Appl. Chem., 72, 333 (2000).
• 13. Bel A., Martinod E. and Menasche P., Acta Haematologica, 95, 63 (1996).
• 14. McBryde W.A.E. and Atkinson G.F., Can. J. Chem., 39, 510 (1961).
• 15. Makańova J., Šima J., Brezova V. and Elias H., In Progress in Coordination and Organometallic Chemistry (Eds. G. Ondrejovič, A. Sirota), STU Press, Bratislava (1997) p. 201.
• 16. Ellis B.L., Duhme A.K., Hider R.C., Hossain M.B., Rizvi S. and ven der Helm D., J. Med Chem   39 3659(1996).
• 17. Melnik M., Ondrejkovičova L, Vančova V. and Holloway C.E., Rev. Inorg. Chem., 17, 55 (1997).
• 18. Funahashi S. and Inada Y, Bull. Chem. Soc. Japan, 75, 1901 (2002).
• 19. Kotani T., Ichimoto H. and Jatsumi Ch., J. Ferment. Technol, 51, 66 (1973).
• 20. Momoki K., Sekino J., Sato H. and Yamaguchi N., Anal. Chem., 41, 1285 (1969).
• 21. Hartley F.R., Burgess C. and Alcock R.M., Solution Eąuilibria, Ellis Horwood, New York, 1980.
• 22. Petrola R., Finn. Chem. Lett., 201 (1985).
• 23. Kotrly S. and Sucha L., Chemical Equilibria in Analytical Chemistry, SNTL Praha, (1988) (in Czech).
• 24. Grenthe L, Chemical Thermodynamics of Uranium, NEA, North-Holland, Amsterdam, (1992).