Transition Metal Manganese(II), Nickel(II), Copper(II) and Zinc(II) Complexes of a New Schiff Base Ligand: Synthesis, Characterization and Antitumor Activity Studies

• Autorzy: Yang T. , Qin W.
• Języki publikacji: EN

Abstrakty

EN

Four transition metals complexes ([Mn(L)2] (complex 1), [Ni(L)20.5H2O] (complex 2), [Cu(L)24H2O] (complex 3) and [Zn(L)20.5H2O] (complex 4)), which contain a new Schiff base ligand (HL) derived from 2,4-dihydroxylacetophenone with triaminotriethylamine, have been synthesized and subsequently characterized by element analysis, 1HNMRand mass spectra. Their properties have been investigated by IR, UV and TG-DTA techniques. Tentative structures for the complexes have been proposed based on the experimental results. The antitumor activity against HL-60 human leukemia cells of free ligand (L) and its Mn(II), Ni(II), Cu(II) complexes were also studied by MTT method. The Ni(II) complex shows the best antitumor activity properties among these complexes.

Słowa kluczowe

EN

Schiff base ligand; transitionmetals complexes; synthesis; characterization; antitumor activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 10
• Strony: 1657--1662
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Yang T.

autor

Qin W.

• Key Lab of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, Ningxia, 750021, P.R. China

Bibliografia

• 1. Frausto da Silva J.J. and Williams R.J.R, The Biological Chemistry of the Elements, Clarendon Press, Oxford, 1991, p. 302.
• 2. Endeben A. and Schumacher D., Eur. J. Inorg. Chem., 3039 (2001).
• 3. Yu S.Y., Wang S.X., Luo Q.H. and Wang L.F., Polyhedron, 12,1097 (1993).
• 4. Li J., Tang S.M., Zhang F.X., Tang Z.X., Shi Q.Z., Wu QJ. and Huang Z.X., Chinese J. Inorg. Chem., 16, 84 (2000).
• 5. Chen H.L., Hań D.Y., Hań H., Tang W.X., Yang Y. and Yang W.T., Acta Cryst., C52, 2204 (1996).
• 6. Padhy S. and Kauffman G.B., Coord. Chem. Rev., 63,127 (1985).
• 7. Garoufis A., Kasselouri S., Katehanakis A., Kalkanis S., Gerlepes S.P. and Hadjiliadis N., Inorg. Chim. Acta, 207,255 (1993).
• 8. Yang T.L., Xiao Z.F, Qin W.W. and Liu W.S., Polish J. Chem., 78 , 601 (2004).
• 9. Yang T.L., Qin W.W. and Liu W.S., Talanta, 62,451 (2004).
• 10. Patricia R and Trevor J.M., Cancer Res„ 50,1392 (1990).
• ll. Geary W.J., Coord. Chem. Rev.,7, 81 (1971).
• 12. Elicchi Ferrari M.B., Capacchi S., Bisceglie F., Pelosi G. and Tarasconi R, Inorg. Chim. Acta, 32,81(2001).
• 13. Nakamoto K., Infrared and Raman Spectra of Inorganic and Coordination Compounds, NY: Wiley & Sons, 1978.
• 14. Dodoff N., Grancharow K. and Gugova R., J. Inorg. Biochem., 54, 212 (1994).