Modelling the frequencies of chromosomal aberrations in peripheral lymphocytes of patients undergoing radiotherapy

• Autorzy: Urbanik W. , Kukołowicz P. , Kuszewski T. , Góźdź S. , Wójcik A.
• Języki publikacji: EN

Abstrakty

EN

Recently, several attempts have been undertaken to correlate in vitro calibration curves with observed frequencies of chromosomal aberrations and micronuclei in lymphocytes of patients undergoing radiotherapy. The aim of such correlations is the search for a biological method to reconstruct the dose received during radiotherapy. While the in vitro dose-response curves are linear-quadratic, the observed in vivo relationship is usually linear and there is some controversy as to the nature of the observed linearity. We have, therefore, constructed a model to calculate the frequencies and distributions of chromosomal aberrations in lymphocytes of patients undergoing conventional radiotherapy. The model assumes that each fraction of radiation induces a certain number of Poisson-distributed aberrations in the irradiated blood volume. In addition, a simplified assumption is made that lymphocytes flow freely inside the body of the patient and no elimination of cells occurs. The model yields linear dose response curves. The steepness of the curves increases with increasing size of irradiated block of tissue (referred to as irradiated volume) and increasing dose per fraction. The distributions of aberrations become increasingly overdispersed with increasing dose per fraction but are independent of the number of radiation fractions. The modelled dose-response curves agree well with the majority of published experimental results. Given the simple assumptions made, this indicates that cell elimination, which occurs during radiotherapy does not bias the results obtained experimentally. The linearity of the dose response-curve results from the fractionated irradiation. Hence, great care should be applied when attempting to use standard, linear-quadratic calibration curves to estimate the doses received by patients during radiotherapy.

Słowa kluczowe

EN

biological dosimetry; chromosomal aberration; peripheral lymphocytes; radiotherapy

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2003
• Tom: Vol. 48, nr 1
• Strony: 3--8
• Opis fizyczny: Bibliogr. 24 poz., rys.

Twórcy

autor

Urbanik W.

• Department of Inorganic Chemistry, Economic Academy, 118/120 Komandorska Str., 53-345 Wrocław, Poland

autor

Kukołowicz P.

• Świętokrzyskie Oncology Center, 3 Artwińskiego Str., 25-734 Kielce, Poland

autor

Kuszewski T.

• Świętokrzyskie Oncology Center, 3 Artwińskiego Str., 25-734 Kielce, Poland

autor

Góźdź S.

• Świętokrzyskie Oncology Center, 3 Artwińskiego Str., 25-734 Kielce, Poland

autor

Wójcik A.

• Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, 16 Dorodna Str., 03-195 Warsaw, Poland, Tel.: [phone], Fax: [phone]
• Department of Radiation Biology and Immunology, Świętokrzyska Academy, 15 Świętokrzyska Str., 25-406 Kielce, Poland

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