Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies

• Autorzy: Rowshanfarzad P. , Jalilian A. , Kiyomarsi M. , Sabet M. , Karimian A. , Moradkhani S. , Mirzaii M.
• Języki publikacji: EN

Abstrakty

EN

Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.

Słowa kluczowe

EN

rubidium-82m; quality control; animal study; cyclotron

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2006
• Tom: Vol. 51, nr 4
• Strony: 209--215
• Opis fizyczny: Bibliogr. 17 poz., rys.

Twórcy

autor

Rowshanfarzad P.

autor

Jalilian A.

autor

Kiyomarsi M.

autor

Sabet M.

autor

Karimian A.

autor

Moradkhani S.

autor

Mirzaii M.

• Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine (NRCAM), Atomic Energy Organization of Iran (AEOI), Moazzen Blvd., Rajaee shahr, Karaj, Iran, P. O. Box 31485-498, Tel.: [phone], Fax: +98 261,

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