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Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.
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Tom
Strony
209--215
Opis fizyczny
Bibliogr. 17 poz., rys.
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autor
autor
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autor
autor
- Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine (NRCAM), Atomic Energy Organization of Iran (AEOI), Moazzen Blvd., Rajaee shahr, Karaj, Iran, P. O. Box 31485-498, Tel.: +98 261 4436397, Fax: +98 261, ajalilian@nrcam.org
Bibliografia
- 1. Aboudzadeh M (1998) Selection of the proper nuclear reaction for the production of Kr-81m. IAEA Bull 17:41−43
- 2. Bateman TM (2004) Cardiac positron emission tomography and the role of adenosine pharmacologic stress. Am J Cardiol 94;2A:19D−24D
- 3. Blann M, Bislinghoff J (1991) Code Alice/Livermore 91.Lawrence Livermore National Laboratory, Internal Report, UCID-19614
- 4. Cherry SR, Carnochan P, Babich JW, Serafini F, Rowell NP, Watson IA (1990) Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography. J Nucl Med 31;8:1307−1315
- 5. Jalilian AR, Mirzaii M, Rowshanfarzad P et al. (2004) Production, formulation, quality control, biodistribution and imaging properties of [18F]-KF in normal rats for PET applications. Iran J Nucl Med 21:49−62
- 6. Jalilian AR, Rowshanfarzad P, Sabet M, Novinrooz A,Raisali G (2005) Preparation of [66Ga]Bleomycin complex as a possible PET radiopharmaceutical. J Radioanal Nucl Chem 264;3:617−621
- 7. Kopecky P, Szelecsenyi F, Molnar T, Mikecz P, Tarkanyi F (1993) Excitation functions of (p,xn) reaction on natTi,monitoring of bombarding proton beams. Int J Appl Radiat Isot 44;4:687−692
- 8. Lambrecht RM, Gallagher BM, Wolf AP, Bennett GW (1980) Cyclotron isotopes and radiopharmaceuticals-XXIX. 81,82mRb for positron emission tomography. Int J Appl Radiat Isot 31;6:2836−2842
- 9. McGowan RL, Welch TG, Zaret BL, Bryson AL, Martin ND, Flamm MD (1976) Non-invasive myocardial imaging with potassium-43 and rubidium-81 in patients with left bundle branch block. Am J Cardiol 38;4:422−428
- 10. Marwick TH, Shan K, Patel S, Go RT, Lauer MS (1997)Incremental value of rubidium-82 positron emission tomography for prognostic assessment of known or suspected coronary artery disease. Am J Cardiol 80;7:865−870
- 11. Murata K (1989) Usefulness and limitations of myocardial scintigraphy at present. J Cardiol 19:593−597
- 12. Pirich C, Schwaiger M (2000) The clinical role of positron emission tomography in management of the cardiac patient. Rev Port Cardiol 19:89−100
- 13. Shea MJ, Wilson RA, Wilson CM et al. (1987) Use of short and long-lived rubidium traces for the study of transient ischemia. J Nucl Med 28:989−997
- 14. Stoll HP, Huwer H, Vollmar B et al. (2000) Experimental validation of a new coronary guide wire labeled with rubidium 81/krypton 81m for continuous assessment of myocardial blood flow. J Nucl Cardiol 7;3:255−262
- 15. Vogel AI (1976) A textbook of macro and semimicro qualitative inorganic analysis, 4th ed. Longman, Hong Kong
- 16. Von Dahl J (2001) Assessing myocardial perfusion with positron emission tomography. Z Kardiol 90;11:835−847
- 17. Williams KA, Ryan JW, Resnekov L et al. (1989) Planar positron imaging of rubidium-82 for myocardial infarction, a comparison with thallium-201 and regional wall motion. Am Heart J 118;3:601−610
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Bibliografia
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