Preparation and biodistribution of [201Tl](III)vancomycin complex in normal rats

• Autorzy: Jalilian A. , Hosseini M. , Karimian A. , Saddadi F. , Sadeghi M.
• Języki publikacji: EN

Abstrakty

EN

Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 š 1% by RTLC. A specific activity of about 4.14 x 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.

Słowa kluczowe

EN

thallium-201; vancomycin; labeling; SPECT; radiopharmaceuticals; infection

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2006
• Tom: Vol. 51, nr 4
• Strony: 203--208
• Opis fizyczny: Bibliogr. 18 poz., rys.

Twórcy

autor

Jalilian A.

autor

Hosseini M.

autor

Karimian A.

autor

Saddadi F.

autor

Sadeghi M.

• Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine (NRCAM), Atomic Energy Organization of Iran (AEOI), Moazzen Blvd., Rajaee shahr, Karaj, Iran, P. O. Box 31485-498, Tel.: [phone], Fax: +98 261,

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