Development of [66Ga]oxine complex; a possible PET tracer

• Autorzy: Jalilian A. , Rowshanfarzad P. , Sabet M. , Rahiminejad-Kisomi A. , Rajamand A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 š 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.

Słowa kluczowe

EN

gallium-66; oxine; positron emission tomography; blood cell labeling; stability

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2006
• Tom: Vol. 51, nr 3
• Strony: 155--159
• Opis fizyczny: Bibliogr. 21 poz., rys.

Twórcy

autor

Jalilian A.

autor

Rowshanfarzad P.

autor

Sabet M.

autor

Rahiminejad-Kisomi A.

autor

Rajamand A.

• Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine (NRCAM), Atomic Energy Organization of Iran (AEOI), Moazzen Blvd., Rajaee shahr, Karaj, Iran, P. O. Box 31485-498, Tel.: [phone], Fax: +98 261,

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