Cross-coupling Reactions for Steroid Modification: from Arylation to Macrocycle Syntheses

• Autorzy: Lukashev N. , Averin A. , Latyshev G. , Donez P. , Ranyuk E. , Beletskaya I.
• Języki publikacji: EN

Abstrakty

EN

The Suzuki-Miyaura coupling of 4- and 6-halosteroids affords good to excellent yields of potential aromatase inhibitors.While the reaction with 4- and 6-bromo derivatives is catalyzed by Pd(PPh3)2Cl2, the coupling with 6-chloro steroid (chlormadinone acetate) requires the use of Pd(dppb)Cl2 or Pd(dppf)Cl2. The palladium-catalyzed amination of bis(3-bromophenyl) ether of (5_)-cholane-3,24-diol with different polyamines leads to new macrocycles comprising one steroid and one polyamine fragments. Possibility of synthesis of macrocyclodimers containing two steroid and two polyamine fragments have been investigated.

Słowa kluczowe

EN

cross-coupling; palladium; nickel; steroids; chlormadinone acetate; Suzuki reaction; litocholic acid; polyamines; macrocycles; catalysis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 4
• Strony: 559--572
• Opis fizyczny: Bibliogr. 35 poz.

Twórcy

autor

Lukashev N.

autor

Averin A.

autor

Latyshev G.

autor

Donez P.

autor

Ranyuk E.

autor

Beletskaya I.

• The Department of Chemistry, Moscow State Lomonosov University, 119992, Moscow, Russia

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