Synthesis and Antiproliferative Activity in vitro of New 2-Aminobenzimidazole Derivatives. Part 3 [1]. Reactions of 2-Arylideneaminobenzimidazole with Selected 1,3-Diketones

• Autorzy: Nawrocka W. , Sztuba B. , Dryś A. , Wietrzyk J. , Kosendiak J. , Opolski A.
• Języki publikacji: EN

Abstrakty

EN

A series of pyrimido[1,2-a]benzimidazole derivatives has been synthesized in the reactions of 2-aminobenzimidazole Schiff bases 1-6 with selected _-diketones; acetylacetone 7-12 or benzoylacetone 13-18. The structures 4, 7-18 were confirmed by the results of elemental analysis and their IR, 1H NMR and MS spectra. Compounds 4, 7-18 were examined for their antiproliferative activityin vitro against 3 cancer cell lines: P338 (mice leukemia), A549 (non-small cell lung carcinoma), SW707 (rectal adenocarcinoma), using SRB (sulphorhodamine B) or MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide) technique. The Schiff base 4 and tricyclic derivatives 9, 14, 16 exhibited the highest cytotoxic activity in vitro.

Słowa kluczowe

EN

2-aminobenzimidazole; Schiff bases; 1,3-diketones; pyrimido[1,2-a]benzimidazole; antiproliferative activity in vitro

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2006
• Tom: Vol. 80, nr 2
• Strony: 279--287
• Opis fizyczny: Bibliogr. 19 poz.

Twórcy

autor

Nawrocka W.

autor

Sztuba B.

autor

Dryś A.

autor

Wietrzyk J.

autor

Kosendiak J.

autor

Opolski A.

• Department of Technology of Drugs, Wroclaw University of Medicine, 50-140 Wroclaw, Nankier Sq. 1, Poland

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