Geometry of alfa-Diaryl Type CH-NH Acids of Pharmacological Interest. Crystal Structures of alfa-(4-Chlorophenyl)- and alfa-(2,4-Dichlorophenyl-alfa-2-pyrazilideneacetonitrilles

• Autorzy: Główka M. , Olczak A. , Bojarska J. , Szczesio M. , Kozłowska K. , Foks H.
• Języki publikacji: EN

Abstrakty

EN

alfa-Diarylacetonitriles represent a very interesting model for studying the structure-activity relationship, due to restricted freedom of conformational diversity and, on the other hand, a very wide range of biological activities, including analgesic, non-narcotic antiinflammatory and antirheumatic. The two studied representatives have in the crystal state very uniform molecular structures, which may be characterized by a dihedral angle between the two aromatic rings, being 77 graduate in 4-chlorophenyl; 74 graduate and 80 graduate in 2,4-dichlorophenyl derivative, respectively. Despite the presence of groups capable of weak C-H hydrogen bonds formation there is only one short C-H...X contact (X = N in 4 position of the pyrazinyl ring) of 2.40 ?, being significantly shorter than the sum of van der Waals radii of respective atoms. The contact found in the 2,4-dichlorophenyl derivative crystal is in accord with CH-NH proton transfer observed in these compounds.

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2005
• Tom: Vol. 79 / nr 8
• Strony: 1275--1284
• Opis fizyczny: Bibliogr. 35 poz., rys.

Twórcy

autor

Główka M.

• Institute of General and Ecological Chemistry, Technical University of Łódź,ul. Żeromskiego 116, 90-924 Łódź, Poland

autor

Olczak A.

• Institute of General and Ecological Chemistry, Technical University of Łódź,ul. Żeromskiego 116, 90-924 Łódź, Poland

autor

Bojarska J.

• Institute of General and Ecological Chemistry, Technical University of Łódź,ul. Żeromskiego 116, 90-924 Łódź, Poland

autor

Szczesio M.

• Institute of General and Ecological Chemistry, Technical University of Łódź,ul. Żeromskiego 116, 90-924 Łódź, Poland

autor

Kozłowska K.

• Institute of General and Ecological Chemistry, Technical University of Łódź,ul. Żeromskiego 116, 90-924 Łódź, Poland

autor

Foks H.

• Department of Organic Chemistry, Medical University of Gdañsk, Al. Hallera 107, 80-416 Gdańsk, Poland

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