Studies on the Distribution of Mefenamic Acid in Two-Phase Systems: Aromatic Solvent-Water

• Autorzy: Zapała L. , Kalembkiewicz J. , Szlachta J.
• Języki publikacji: EN

Abstrakty

EN

The detailed description of equilibria of mefenamic acid in the aqueous solutions and in the two-phase systems: aromatic solvent - water was made. Isoelectric point, pHI, dissociation constants of the protonated form,Ka1, and the neutral form,Ka2, in the aqueous solutions were determined. On the basis of the spectrophotometric investigations the values of the distribution ratio, D, of mefenamic acid were obtained. Employing the results of the potentiometric titration in the two-phase systems, organic solvent - water, and using models of singular and multistep equilibrium the values of the partition constants, KD, and dimerization constants, Kd, were calculated. The significant influence of the polarity of the applied organic solvents and of pH of the aqueous phase on the percentage of the particular forms of mefenamic acid in the two-phase systems were proved. Key words: mefenamic acid, liquid-liquid distribution, two-phase systems equilibria

Słowa kluczowe

EN

mefenamic acid; liquid-liquid distribution; two-phase systems equilibria

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2005
• Tom: Vol. 79 / nr 7
• Strony: 1235--1244
• Opis fizyczny: Bibliogr. 17 poz., rys.

Twórcy

autor

Zapała L.

• Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Technology,35-959 Rzeszów, Poland

autor

Kalembkiewicz J.

• Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Technology,35-959 Rzeszów, Poland

autor

Szlachta J.

• Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Technology,35-959 Rzeszów, Poland

Bibliografia

• 1.Podlewski J.K. and Chwalibogowska-Podlewska A., Medicaments of the contemporary therapy, (in Polish), Büchner’s Foundation Publishers, 15 (2001).
• 2.European Pharmacopoeia, Council of Europe, Strasbourg, 4 (2001).
• 3.The Merck Index, MERCK & CO., INC, 12 (1996).
• 4.Ito J„ Kato H. et al„ Jap. Patent Nr 59-175220 (1986).
• 5 Kancki H., Jamaguti M. and Sado E., Jap. Patent Nr 61-134541 (1988).
• 6. Kimura I., Yoshida M. and Sato I., Yakuri to Chiryo, 13,2797 (1985), CA: 103, 153586r (1985).
• 7.Brzyska W. and Ożga W., Polish J. Chem., 67, 619 (1993).
• 8.Bojarowicz H. and Zommer-Urbanska S., Acta Polon. Pharm., SO, 285 (1993).
• 9.Romero S., Escalera P. and Bustamante P., Int. J. Pharm., 178, 193 (1999).
• 10.Takas-Novak K., Avdeef A., Box K.J., Podanyi B. and Szasz G., J. Pharm. Biomed. Anal., 12 (1994).
• 11.Ong K.C. Robinson R.A. and Bates R.G., Anal. Chem., 36, 1971 (1964).
• 12.FallavenaP.R. and Schapoval E.E., Int. J. Pharm., 158, 109 (1997).
• 13.Kopacz S., Papciak B. and Kalembkiewicz J., Zh. Obshch. Khim., 67, 294 (1997).
• 14.Kalembkiewicz J., Zh. Obshch. Khim., 60, 1686 (1990).
• 15.Kalembkiewicz J., Brunette J.-P. and Leroy M.J.F., Monatsh. Chem., 120, 691 (1989).
• 16.Kopacz S., Papciak B. and Kalembkiewicz J., Zh. Obshch. Khim., 63,283 (1993).
• 17.Papciak B., Investigations of the electrolytes influence on the extraction cation exchange systems (in Polish). Ph. D Thesis, Maria Curie-Skłodowska University, Lublin 2000.