alfa-Aminoalkylphosphonates Induced Apoptosis in Human Tumor Cell Lines

• Autorzy: Drąg M.
• Języki publikacji: EN

Abstrakty

EN

Evaluation of the in vitro activity of the 1-amino-3-phenylpropanephosphonic acid and diphenyl 1-(N-benzyloxycarbonylamino)-1-(4-amidinophenyl)methanephosphonate hydrochloride toward acute, human Jurkat and A549 cell lines revealed that these compounds are potent inducers of apoptosis. Their potency to inhibit proliferation of tested tumor lines is similar to bestatin, a well-known inhibitor of aminopeptidases and strong inducer of apoptosis in the number of cancer cell. In this paper preliminary experimental details as well as the possible mechanism of action of alfa-aminoalkylphosphonates will be discussed.

Słowa kluczowe

EN

alfa-aminoalkylphosphonates; apoptosis; cancer; aminopeptidase; comet assay

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2005
• Tom: Vol. 79 / nr 3
• Strony: 593--602
• Opis fizyczny: Bibliogr. poz. 13, rys.

Twórcy

autor

Drąg M.

• Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

Bibliografia

• 1.Aminophosphanic and Aminophosphinic adds: Chemistry and Biological Activity, Kukhar V.P., Hudson H.R., Eds.; John Wiley; New York (2000).
• 2.(a) Logusch E.W., Walker D.M., McDonald J.F., Leo G.C. and Franz J.K., .J. Org. Chem., 53, 4069 (1988); (b) Logusch H.W., Walker D.M., McDonald J.F. and Franz J.H., Biochemistry, 28, 3043 (1989); (e) Cope V., Farad S., Walsh C.T. and Griffin R.G., Biochemistry, 27, 4966 (1988); (d) Lejczak 15., Kafarski P. and Makowiecka H., Biochem .J. 247 , 81 (1987); (c) Janas K., Filipiak A., Kowalik J., Mastalerz P. and Knypl J.S., Acta Biochim. Polonica,32, 131 (1985); (c)Zoń J. and Amrhein M., Liebigs Ann. Chem., 625 (1992); (f) Lejczak B., Kafarski P. and Zygmunt J., Biochemistry, 28, 3549 (1989); (g) Perkins M.N., Stone T.W., Collins J.F. and Curry K., Neurosci. Lett., 23, 333 (1981); (h) Acbischer B., Frey P., Haerter H.P., Herrling P.L. and Müller W.; Helv. Chim. Acta, 72, 1043 (1989).
• 3.(a)Oleksyszyn J., Tyka R. and Mastelerz P., Synthesis, 479 (1978); (b) Kafarski P., Lejczak B. and Szewczyk J., Can. J. Chem., 61,2425 (1983); (c) Soroka M., Jaworska Z. and Szczęsny Z., Liebigs. Ann. Chem., 1153 (1990); (d) Kowalik J., Kupczyk-Sobótkowska P. and MastalerzP.,Synthesis, 57(1981); (e) Oleksyszyn J., Boduszek B., Kam C.M. and Powers J.C., J. Med. Chem., 27,226 (1994); (i) Haniilton R., Walker B. and Walker B.J., Tetrahedron Lett., 36, 4451 (1995).
• 4.Umezawa H., Aoyagi T., Suda H., Hamada M. and Takeuchi T., J. Antibiot., 29, 97 (1976).
• 5.(a) Ezawa K., Minato K. and Dobashi K., Biomed. Pharmacother., 50, 283 (1996); (b) Saiki I., Fuji H., Yoncda J., Abe F., Nakajima N., Tsuruo T. and Azuma I., Int. J. Cancer, 54, 137 (1993); (c) Sekine K., Fuji H. and Abe F., Leukemia, 13, 720 (1999); (d) Sekine K., Fuji H., Abe F. and Hishikawa K., Int. J. Cancer, 94, 485 (2001).
• 6.Scomik O.A. and Botbol V., Curr. Drug Metabolism, 2, 67, (2001).
• 7.Melzig M.F. and Borman H., Planta Med., 64, 655, (1998).
• 8.(a) Drąg-Zalesińska M., Wysocka T., Dumańska M., Jagoda E. and Zabel M., Folia Histochemica et Cytobiologica, 40, 125 (2002); (b) Drąg-Zalesińska M., Wysocka T., Gębarowska E. and Zabel M., Folia Histochemica et Cytobiologica, 37, 133 (1999).
• 9.Yasuhara S., Zhu Y., Matsui T., Tipimcni N., Yasuhara Y., Kaneki M., Rosenzweig A. and Jeevendra-Marlyn J.A., J. Histochem. Cytochem., 51, 873 (2003).
• 10.Collins A.R., Methods Mol. Biol., 203, 163 (2002).
• 11.Marcinkowska A., unpublished results.
• 12.(a) Kanayama N., Kajiwara Y. and Goto J.,.J. Leukoc. Biol., 57, 129 (1995); (b) Dong X., An B. and Salvucci Kierstead L., J. Immunolog., 164, 129 (2000).
• 13.(a) Genes into Drugs-, Rodney J., Ho Y. and Gibaldi M., Eds.; John Wiley; New York, 171 (2003); (b) Joossens J., Van der Veken P., Lambeir A.-M., Augustyns K. and Haemers A., J. Med. Chem. 47, 2411 (2004).