(E)-Cinnamic Acid Analogues as Inhibitors of Phenylalanine Ammonia-Lyase and of Anthocyanin Biosynthesis

• Autorzy: Kluczyk A.
• Języki publikacji: EN

Abstrakty

EN

Several carboxylic, phosphonic, phosphinic, boronic and nitro analogues of (E)-cinnamic acid were synthesized. These and other compounds related to (E)-cinnamic acid were evaluated as potential inhibitors of both phenylalanine ammonia-lyase and of anthocyanin biosynthesis in buckwheat. The most potent inhibition was found for 3-phenylprop-2-ynoic acid (21), however its Ki is comparable to KM. The molecular modelling of the interaction of (E)-cinnamic acid (1) and 21 with PAL model suggests some similarities in the binding mode of both compounds.

Słowa kluczowe

EN

phenylalanine ammonia-lyase; enzyme inhibitors; molecular modelling; anthocyanin biosynthesis; phenylpropanoid pathway

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2005
• Tom: Vol. 79 / nr 3
• Strony: 583--592
• Opis fizyczny: Bibliogr. poz. 42, rys.

Twórcy

autor

Kluczyk A.

• Faculty of Chemistry, Wrocław University, F. Joliot-Curie 14, 50-383 Wrocław, Poland

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