Cyclic Analogues of Proline-Rich Protein Fragments : part III. Synthesis of New Analogues, Conformational Studies and Evaluation of Immunotropic Activity

• Autorzy: Wirkus-Romanowska I. , Rodziewicz-Motowidło S. , Miecznikowska H. , Rolka K. , Janusz M. , Szymaniec S. , Zabłocka A. , Fortuna W. , Międzybrodzki R. , Lisowski J. , Kupryszewski G.
• Języki publikacji: EN

Abstrakty

EN

The immunotropic activity of peptides studied evaluated in the murine system indicated that they are as active as the linear precursor in the resistance to hydrocortisone, but did not show activity in the human system. As reported previously, similar immunotropic profiles were observed in the case of two cyclic analogues. Superposition of most representative conformations of all four peptides in the fragment mentioned above (RMSD of A carbons is0.86 A) leads to the conclusion that this hexapeptide segment might be considered as bioactive.

Słowa kluczowe

EN

cyclic PRP fragments; solid peptide synthesis; conformational studies; 2D NMR; immunotropic activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2000
• Tom: Vol. 74, nr 8
• Strony: 1129--1141
• Opis fizyczny: Bibliogr. 20 poz., rys.

Twórcy

autor

Wirkus-Romanowska I.

• Faculty of Chemistry, University of Gdańsk 80-952 Gdańsk, Poland

autor

Rodziewicz-Motowidło S.

• Faculty of Chemistry, University of Gdańsk 80-952 Gdańsk, Poland

autor

Miecznikowska H.

• Faculty of Chemistry, University of Gdańsk 80-952 Gdańsk, Poland

autor

Rolka K.

• Faculty of Chemistry, University of Gdańsk 80-952 Gdańsk, Poland

autor

Janusz M.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Szymaniec S.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Zabłocka A.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Fortuna W.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Międzybrodzki R.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Lisowski J.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland

autor

Kupryszewski G.

• Faculty of Chemistry, University of Gdańsk 80-952 Gdańsk, Poland
• Institute of Oceanology, Polish Academy of Sciences, 81-712 Sopot, Poland

Bibliografia

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