Kinetics and Mechanism of Oxidative transformations of (6R)-6-(A-Phenyl-D-glycylamino)penicillanic Acid (Ampicillin) by Manganese(III) in Pyrophosphate Medium

• Autorzy: Subrahmanyam E. , Ishwar Bhat K. , Sherigara B. , Satyanarayana D.
• Języki publikacji: EN

Abstrakty

EN

Manganese(III) has been stabilized in weakly acidic solution by pyrophosphate and the compklex Formed was elucidated spectrophotoetrically. Stoichiometry of magnese (III) oxidation of apicillin in pyrophosphate medium was establishesd in the pH range 2.0-3.0 by iodometric and spectrophotometric methods.The oxidation follows first order kinetics in [Mn(III)]. The effect of varying [Mn(III)], [Amp], [H+], added [Mn(II)], total[P2O7 4-] and added[ClO-4],[SO4 2-] ions have been studied. The order in [Amp] is unity and increase in [H=] increases the rate. With increase in [Mn(II)] and [P2O4- 7], a retardation effect was noticed. Oxidation products have been proposed. Dependence of reaction rate on temperature has been studied and activation parameters were computed. A mechanism consistent with the observed results has been proposed.

Słowa kluczowe

EN

manganese(III); pyrophosphate; ampicillin; oxidation; penicilic acid

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2000
• Tom: Vol. 74, nr 6
• Strony: 793--800

Twórcy

autor

Subrahmanyam E.

autor

Ishwar Bhat K.

autor

Sherigara B.

autor

Satyanarayana D.

• NGSM Institute of Pharmaceutical Sciences Nanthoor, Mangalore India