Fragments of a Proline-Rich Polypeptide Settled on a Hexapeptide Carcass Constructed of Glycine and L-Lysine Residues : Synthesis and Biological Properties

• Autorzy: Wirkus-Romanowska I. , Miecznikowska H. , Zablocka M. , Rybka K. , Fortuna W. , Międzybrodzki R. , Szymaniec S. , Janusz M. , Lisowski J. , Kupryszewski G.
• Języki publikacji: EN

Abstrakty

EN

Proline-rich polypeptide fragments settled on a hexapeptide constructed od L-lysine and glycine residues were synthesized by the solid phase method: X-Lys(X)-Gly-Lys(X)-Gly-Lys(X)-Gly-OH, X= Tyr-Val-Pro-Leu-Phe-Pro and Y-Lys(Y)-Gly-Lys(Y)-Gly-Lys(Y)-Gly-OH, Y=Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro. Imunotropic activity of the analogues was determined in a murine syste using resistance to hydrocortisone and in human cell cultures using induction of cytokines as indicators.

Słowa kluczowe

EN

PRP fragments; solid phase peptide synthesis; immunotropic activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2000
• Tom: Vol. 74, nr 2
• Strony: 219--225
• Opis fizyczny: Bibliogr. 20 poz., rys.

Twórcy

autor

Wirkus-Romanowska I.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdansk, Sobieskiego 18

autor

Miecznikowska H.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdansk, Sobieskiego 18, Poland

autor

Zablocka M.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Rybka K.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Fortuna W.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Międzybrodzki R.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Szymaniec S.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Janusz M.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Lisowski J.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Rudolfa Weigla 12, Poland

autor

Kupryszewski G.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdansk, Sobieskiego 18, Poland

Bibliografia

• 1. Janusz M., Lisowski J. and Franek F., FEBS Lett., 49, 276 (1974).
• 2. Janusz M., Starościk K., Zimecki M., Wieczorek Z. and Lisowski J., Biochem. J., 199, 9 (1981).
• 3. Janusz M. and Lisowski J., Arch. Immunol. Ther. Exp., 41, 275 (1993).
• 4. Wieczoiek Z., Zimecki M., Janusz M., Starościk K. and Lisowski J., Immunology, 36, 875 (1979).
• 5. Zimecki M., Janusz M., Starościk K., Lisowski J. and Wieczorek Z., Immunology, 47, 141 (1982)
• 6. Janusz M. and Błaszczyk B., Arch. Immunol. Ther. Exp., 44, 23 (1996).
• 7. Inglot A.D., Janusz M. and Lisowski J., Arch. Immunol. Ther. Exp., 44, 215 (1996).
• 8. Popik P., Bobula B., Janusz M., Lisowski J. and Ventulani J., Pharmacol. Biochem. Behavior, in press.
• 9. Starościk K., Janusz M.,Zimecki M., Wieczorek Z. and Lisowski J., Molec. Immunol.,20,1227(1983).
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• 12. Deflos M.L., He Y.W., Ojala E.W. and Bevan M.J., Immunity, 9, 111 (1998).
• 13. Lu G.-S., Mojsor S. and Merrifield R.B., Int. J. Pept. Protein Res., 29, 545 (1987).
• 14. Barany G. and Merrifield R.B., The Peptide Analysis, Synthesis, Biology. (Eds. Gross E., Meienhofer J.), Academic Press, NY, 1980, p. 1.
• 15. Gisin B.F., Helv. Chim. Acta, 56, 1476 (1973).
• 16. Kaiser J.E., Colescott R.C., Bossinger C.A. and Cook D.J., Anal. Biochem., 34, 595 (1970).
• 17. Christensen T., Peptides Structure and Biological Function, (Eds. Gross E., Meienhofer J.), Pierce Chem. Company, Rockford, 1979, p. 358.
• 18. Sakakibara S., Chemistry and Biochemistry of Amino Acid, Peptides and Proteins, vol. 1 (Ed. Weinstein B.), Marcel Dekker, NY, 1971, p. 511.
• 19. Piasecki E., KnyszB., Inglot M., Simon K. and Gładysz A., Arch. Immunol. Ther. Exp.,44,345 (1996).
• 20. Kelso A., Immunol. Cell. Biol., 76, 300 (1998).