Acyclonucleosides of indazole and their rearrangements

• Autorzy: Boryski J.
• Języki publikacji: EN

Abstrakty

EN

2-[(2-Acetoxyethoxy)methyl]indazole (3), a kinetic product formed in the reaction of indazole (1) with 2-acetoxyethyl acetoxymethyl ether (2), undergoes an irreversible, acid-catalyzed isometrization of the 2Ž 1 transglycosylation type to the respective 1-regioisomer (4). In contrast to the purine acyclonucleosides series, however, product 4 undergoes a further rearrangement to the dimmer 5. On the basis of products distribution and kinetics of their formation, a mechanism of these conversions has been proposed and compared to the facile anomerization reactions of indazole ribofuranosides.

Słowa kluczowe

EN

indazole; acyclonucleosides; transglycosylation; dimerization

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1999
• Tom: vol. 73 nr 6
• Strony: 1019--1027

Twórcy

autor

Boryski J.

• Instytut Chemii Bioorganicznej PAN ul. Noskowskiego 12/14 61-704 Poznań,