Molecular structure of two 1-O-acylglycosyl esters of diclofenac

• Autorzy: Kołodziejczyk E. , Suwińska K. , Kozioł A. , Enright G. , Borowiecka J.
• Języki publikacji: EN

Abstrakty

EN

The molecular structure of 8 and 9 has been determined by a single-crystal X-ray analysis. Both chiral esters are derivatives of the non-steroidal anti-inflammatory drug diclofenac (1), and have physicochemical properties of potential prodrug. Comparison of the geometry of 2-[(2,6-dichlorophenyl)amino]phenylacetate fragment, observed in eighteen solid-state structures, shows limited flexibility of 1. Two rotations around bonds linking the o-phenyl ring with the carboxyl and dichlorophenyl groups change their relative orientation, but both groups are nearly perpendicular to the o-phenyl plane. The amino group is involved exclusively in intramolecular contacts.

Słowa kluczowe

EN

diclofenac; voltaren; 1-O-acyl sugars; X-ray analysis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1999
• Tom: vol. 73 nr 2
• Strony: 367--376

Twórcy

autor

Kołodziejczyk E.

autor

Suwińska K.

autor

Kozioł A.

autor

Enright G.

autor

Borowiecka J.

• Wydział Chemii UMCS 20-031 Lublin