A Facile Synthesis of Primary and Secondary Amines

• Autorzy: Łankiewicz L. , Rój A. , Szymańska A. , Wiczk W.
• Języki publikacji: EN

Abstrakty

EN

A facile synthesis of primary amines (R-CH2-NH2, where R = napht-2-yl, anthr-9-yl, phenyl, p-nitrophenyl) and secondary amines (R-NH-R', where R is as mentioned above for primary amines and R'= methyl) is described. The primary amines were obtained by alkylation of di-tert-butyl imidodicarbonate (Boc2NH) under phase-transfer catalysis (PTC) conditions, followed by acidolytic removal of the amine protecting groups. The secondary amines were obtained from the appropriate primary amines by alkylation of their N-tert-butoxycarbonyl derivatives (Boc-NH-R), followed by Boc group acidolysis. It is worth emphasizing that the substrates for synthesis of secondary amines (Boc-NH-R) were obtained via selective removal of one of the tert-butoxycarbonyl groups from the alkylated di-tert-butyl imidodicarbonates (Boc2N-R).

Słowa kluczowe

EN

primary and secondary amine synthesis; di-tert0butyl imidodicarbonate; PTC catalysis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2004
• Tom: Vol. 78 / nr 8
• Strony: 1067--1072
• Opis fizyczny: Bibliogr. 15 poz., rys.

Twórcy

autor

Łankiewicz L.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

autor

Rój A.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland
• Faculty of Business Administration, Gdynia Maritime University, Morska 83, 81-225 Gdynia, Poland

autor

Szymańska A.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

autor

Wiczk W.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

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