Studies on Reactions of 3-Benzoyl-4-hydroxypyrido[3,2-e)-1,2-thiazines with Primary Amines and N-Methylhydrazine

• Autorzy: Malinka W. , Karczmarczyk Z. , Kaczmarz M. , Świątek P. , Urbańczyk-Lipkowska Z.
• Języki publikacji: EN

Abstrakty

EN

Reaction of the appropriate 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazine-1,1-dioxides 2 bearing a methyl or a 3-(4-arylpiperazin-1-yl)propyl group at the nitrogen atom of the thiazine ring with primary amines resulted in enamines of type (E)-3. The related products 8 were obtained by alkylation of 3-phenylpyrazolo[4,3-c]pyrido[3,2-e]-1,2- thiazine-5,5-dioxide 7 with the corresponding 1-aryl-4-(3-chloropropyl)piperazines 9. The structures of the new heterocycles 3 and8, synthesized for pharmaceutical purposes, and of the model compounds 4-6, prepared for comparison of spectral properties, were proven through elemental, IR, 1H NMR and, in some cases (3d, 8a), X-ray data.

Słowa kluczowe

EN

pyrido-1,2-thiazines; pyrazolopyrido-1,2-thiazines; syntheses; X-ray study

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2004
• Tom: Vol. 78 / nr 6
• Strony: 815--829
• Opis fizyczny: Bibliogr. 30 poz., rys.

Twórcy

autor

Malinka W.

• Department of Chemistry of Drugs, Wrocław Medical University, ul. Tamka 1, 50-137 Wrocław, Poland

autor

Karczmarczyk Z.

• Department of Chemistry, University of Podlasie, ul. 3 Maja 54, 08-110 Siedlce, Poland

autor

Kaczmarz M.

• ---
• Department of Chemistry of Drugs, Wrocław Medical University, ul. Tamka 1, 50-137 Wrocław, Poland

autor

Świątek P.

• Department of Chemistry of Drugs, Wrocław Medical University, ul. Tamka 1, 50-137 Wrocław, Poland

autor

Urbańczyk-Lipkowska Z.

• Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/54, 01-224 Warsaw, Poland

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