Synthesis of [3-[2-(Dimethylamino)ethyl]-2-[[3-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-n-methylmethanesulfonamide-the Main Sumatriptane Impurity

• Autorzy: Skwierawska A. , Paluszkiewicz E.
• Języki publikacji: EN

Abstrakty

EN

Alkylation of sumatriptane in position 2 by 3-[2-(dimethylamino)ethyl]-5-indolemethanol has been described. Alternative multistep synthesis of 3-[2-(dimethylamino)ethyl]- 5-indolemethanol has been presented.

Słowa kluczowe

EN

indole derivatives; sumatriptane; drug impurities

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2003
• Tom: Vol. 77 / nr 3
• Strony: 329--332
• Opis fizyczny: Bibliogr. 8 poz., rys.

Twórcy

autor

Skwierawska A.

• Department of Chemistry, Gdańsk University of Technology, 80-952 Gdańsk, ul. Narutowicza 11/12, Poland

autor

Paluszkiewicz E.

• Department of Chemistry, Gdańsk University of Technology, 80-952 Gdańsk, ul. Narutowicza 11/12, Poland

Bibliografia

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• 4. European Pharmacopoeia 2001,1573.
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• 6. Strret L.J., Baker R., Castro J.L., Chambers M.S., Guiblin A.R., Hobbs S.C., Matassa V.G., Reeve A.J., Beer M.S., Middlemiss D.N., Noble A.J., Stanton J.A., Scholey K. and Hargreaves R., J. Med. Chem., 36, 1529(1993).
• 7. Mancuso A.J., Huang S.L. and Swem D., J. Org. Chem., 43, 12 (1978).
• 8. Hughes D.L. and Zhao D., J. Org. Chem., 58, 228 (1993).