Study of the Inclusion Complexes of Catecholamines with beta-Cyclodextrin by Cyclic Voltammetry

• Autorzy: Gao Z. , Wen X. -L. , Li H. -L.
• Języki publikacji: EN

Abstrakty

EN

The inclusion complexes of catecholamines (dopamine, DA, and adrenaline, AD) with beta-cyclodextrin (beta-CD) have been studied by cyclic voltammetry (CV) using glassy carbon electrode (GCE) for expanding the potential window. The variations of peak potential and peak current were observed on cyclic voltammograms, when the electroactive guest molecules, DA and AD are complexed with beta-CD. Dissociation constants of cyclodextrin inclusion complexes have been calculated. The experimental results indicate that bothDAandADcan form a 1:1 inclusion complexes with beta-CD in aqueous solutions. It was observed that the light and oxygen sensitivity of the inclusion complex is much lower than those of the free catecholamines, which can be used to improve their storage and handling, and also widen their applications in pharmaceutical industry. Furthermore, it was found that their electrochemical oxidation in the aqueous solutions could be inhibited by beat-CD.

Słowa kluczowe

EN

catecholamines; beta-CD; inclusion complex; cyclic voltammetry

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 7
• Strony: 1001--1007
• Opis fizyczny: Bibliogr. 16 poz., rys.

Twórcy

autor

Gao Z.

• Department of Chemistry, Ningxia University, 750021, Yinchuan, P. R. China
• Department of Chemistry, Lanzhou University, 730000, Lanzhou, P. R. China

autor

Wen X. -L.

• Department of Chemistry, Ningxia University, 750021, Yinchuan, P. R. China

autor

Li H. -L.

• Department of Chemistry, Ningxia University, 750021, Yinchuan, P. R. China

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