The Efficient Synthesis of Azaamino Acids

• Autorzy: Wieczerzak E. , Kozlowska J. , Łankiewicz L. , Grzonka Z.
• Języki publikacji: EN

Abstrakty

EN

An efficient method of synthesis of N-t-butoxycarbonyl-azaamino acid ethyl esters has been described. This method consisted of three stages including: hydrazone formation, its reduction and acylation with ethyl chloroformate. The second step - reduction of the hydrazones to the appropriate hydrazides - was the most challenging. Some reducing agents have been tested, though NaBH3CN was found to lead to the final products with the highest yields in relatively short time and even to allow the selective reduction of C-N bond in the presence of nitro group.

Słowa kluczowe

EN

azaamino acids; peptidomimetics; selective reduction

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 12
• Strony: 1693--1697
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Wieczerzak E.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

autor

Kozlowska J.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

autor

Łankiewicz L.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

autor

Grzonka Z.

• Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

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