Rate and Equilibrium in Aqueous 1:2 Chelation of Copper(II) by 2-Pyridinecarboxylic Acid Hydrazide. Antituberculosis Activity

• Autorzy: Hernando J. , Blanco C. A. , Caballero I. , Prieto T.
• Języki publikacji: EN

Abstrakty

EN

Chelation reactions of 2-pyridinecarboxylic acid hydrazide, widely used drug in antituberculous regimens, with copper(II) have been investigated in aqueous solution at a temperature of 25_C. The ionization equilibria of the ligand and the stability of the metal-ligand complexes have also been characterized. Kinetic results show that the rate constant for monochelated complex formation is several times larger than the rate constant for dichelated complex formation. Adetailed mechanism is proposed to account for the kinetic data.

Słowa kluczowe

EN

copper(II); 2-pyridinecarboxylic acid hydrazide; kinetics; chelation; antituberculosis activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 12
• Strony: 1673--1680
• Opis fizyczny: Bibliogr. 28 poz., rys.

Twórcy

autor

Hernando J.

• Dpto. Química-Física, Facultad de Ciencias, Universidad de Valladolid, 47005 Valladolid, Spain

autor

Blanco C. A.

• Dpto. Ingeniería Agrícola y Forestal, E.T.S. Ingeniarías Agrarias, Universidad de Valladolid, 34004 Falencia, Spain

autor

Caballero I.

• Dpto. Química-Física, Facultad de Ciencias, Universidad de Valladolid, 47005 Valladolid, Spain

autor

Prieto T.

• Dpto. de Didáctico y Organización Escolar, Facultad de Educación, Universidad de Málaga, Málaga, Spain

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