Analogues of Arginine Vasopressin (AVP) Modified in the N-Thermal Part of the Molecule with N-Benzylglycine

• Autorzy: Jastrzębska B. , Derdowska I. , Kuncarowa P. , Slaninova J. , Lammek B. , B. Olejniczak B. , Zabrocki J.
• Języki publikacji: EN

Abstrakty

EN

The synthesis and some pharmacological properties of five new analogues of arginine vasopressin (AVP) substituted with N-benzylglycine are described. All new peptides were tested for pressor and uterotonic activity. The results obtained imply that the structural change studied is in general incompatible with interaction of the analogues withV1A and OT receptors, however, in combination with suitable additional changes, may be of value in the design of new antagonists of these receptors.

Słowa kluczowe

EN

analogues of arginine vasopressin (AVP); N-benzylglycine; V1A antagonists

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 6
• Strony: 823--830
• Opis fizyczny: Bibliogr. 24 poz., rys.

Twórcy

autor

Jastrzębska B.

• Department of Chemistry, University of Gdańsk, Sobieskiego18, 80-952 Gdańsk, Poland

autor

Derdowska I.

• Department of Chemistry, University of Gdańsk, Sobieskiego18, 80-952 Gdańsk, Poland

autor

Kuncarowa P.

• Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic

autor

Slaninova J.

• Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic

autor

Lammek B.

• Department of Chemistry, University of Gdańsk, Sobieskiego18, 80-952 Gdańsk, Poland

autor

B. Olejniczak B.

• Institute of Organic Chemistry, Technical University, 90-924 Łódź, Poland

autor

Zabrocki J.

• Institute of Organic Chemistry, Technical University, 90-924 Łódź, Poland

Bibliografia

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