Reactions of 5-(2-Dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4-oxadiazole-2-thione with carbon Electrophiles

• Autorzy: Burbuliene M. , Udrenaite E. , Gaidelis P. , Vainilavicius P.
• Języki publikacji: EN

Abstrakty

EN

From 2,4-dichloro-6-methylpyrimidine (1) via esters 2 and 3, (2-dimethylamino-6- methyl-4-pyrimidinylsulfanyl)acethydrazide (4) was synthesized. The latter under treatment either with carbon disulfide in the presence of a base or with potassium O-ethylxanthate in ethanol yielded 5-(2-dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4- oxadiazole-2-thione (5). Alkylation of 5 afforded S-alkyl derivatives 6a,b, whereas aminomethylation, acylation or cyanoethylation gave N(3)-substituted derivatives 7-9. Compounds were tested for their anti-inflammatory activity.

Słowa kluczowe

EN

1,3,4-oxadiazole-2-thiones; anti-inflammatory activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 4
• Strony: 557--563
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Burbuliene M.

• Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania

autor

Udrenaite E.

• Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania

autor

Gaidelis P.

• FacuIty of Medicine, Vilnius University, M.K. Ciurlionio 21, LT-2009, Vilnius, Lithuania

autor

Vainilavicius P.

• Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania

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